Search Results

Overview

Uniprot IDP68255
Protein Name14-3-3 protein theta
Gene NameYwhaq
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
11 TELIQKAKLAEQAER
27 DDMATCMKAVTEQGA
3 *****MEKTELIQKA
68 VISSIEQKTDTSDKK
80 DKKLQLIKDYREKVE
85 LIKDYREKVESELRS
9 EKTELIQKAKLAEQA

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity)

Protein Sequence

10 MEKTELIQKA 20 KLAEQAERYD 30 DMATCMKAVT 40 EQGAELSNEE 50 RNLLSVAYKN 60 VVGGRRSAWR 70 VISSIEQKTD 80 TSDKKLQLIK 90 DYREKVESEL 100 RSICTTVLEL 110 LDKYLIANAT 120 NPESKVFYLK 130 MKGDYFRYLA 140 EVACGDDRKQ 150 TIENSQGAYQ 160 EAFDISKKEM 170 QPTHPIRLGL 180 ALNFSVFYYE 190 ILNNPELACT 200 LAKTAFDEAI 210 AELDTLNEDS 220 YKDSTLIMQL 230 LRDNLTLWTS 240 DSAGEECDAA EGAEN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0045202 synapse
Molecular Function GO:0071889 14-3-3 protein binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0044325 transmembrane transporter binding
Biological Process GO:0008104 intracellular protein localization
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0034766 negative regulation of monoatomic ion transmembrane transport
Biological Process GO:0006605 protein targeting
Biological Process GO:0007165 signal transduction
Biological Process GO:0007264 small GTPase-mediated signal transduction

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.