Search Results

Overview

Uniprot IDP68363
Protein NameTubulin alpha-1B chain
Gene NameTUBA1B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
112 RGHYTIGKEIIDLVL
163 RLSVDYGKKSKLEFS
280 APVISAEKAYHEQLS
304 EPANQMVKCDPRHGK
311 KCDPRHGKYMACCLL
326 YRGDVVPKDVNAAIA
336 NAAIATIKTKRSIQF
338 AIATIKTKRSIQFVD
370 VPGGDLAKVQRAVCM
394 AWARLDHKFDLMYAK
401 KFDLMYAKRAFVHWY
60 FSETGAGKHVPRAVF
96 PEQLITGKEDAANNY

Function

Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661)

Protein Sequence

10 MRECISIHVG 20 QAGVQIGNAC 30 WELYCLEHGI 40 QPDGQMPSDK 50 TIGGGDDSFN 60 TFFSETGAGK 70 HVPRAVFVDL 80 EPTVIDEVRT 90 GTYRQLFHPE 100 QLITGKEDAA 110 NNYARGHYTI 120 GKEIIDLVLD 130 RIRKLADQCT 140 GLQGFLVFHS 150 FGGGTGSGFT 160 SLLMERLSVD 170 YGKKSKLEFS 180 IYPAPQVSTA 190 VVEPYNSILT 200 THTTLEHSDC 210 AFMVDNEAIY 220 DICRRNLDIE 230 RPTYTNLNRL 240 ISQIVSSITA 250 SLRFDGALNV 260 DLTEFQTNLV 270 PYPRIHFPLA 280 TYAPVISAEK 290 AYHEQLSVAE 300 ITNACFEPAN 310 QMVKCDPRHG 320 KYMACCLLYR 330 GDVVPKDVNA 340 AIATIKTKRS 350 IQFVDWCPTG 360 FKVGINYQPP 370 TVVPGGDLAK 380 VQRAVCMLSN 390 TTAIAEAWAR 400 LDHKFDLMYA 410 KRAFVHWYVG 420 EGMEEGEFSE 430 AREDMAALEK 440 DYEEVGVDSV 450 EGEGEEEGEE Y

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005929 cilium
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005881 cytoplasmic microtubule
Cellular Component GO:0005874 microtubule
Cellular Component GO:0015630 microtubule cytoskeleton
Molecular Function GO:0003725 double-stranded RNA binding
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0005200 structural constituent of cytoskeleton
Molecular Function GO:0005198 structural molecule activity
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:0051301 cell division
Biological Process GO:0030705 cytoskeleton-dependent intracellular transport
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0007017 microtubule-based process
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0030182 neuron differentiation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.