Search Results

Overview

Uniprot IDP68366
Protein NameTubulin alpha-4A chain
Gene NameTUBA4A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
112 RGHYTIGKEIIDPVL
163 RLSVDYGKKSKLEFS
164 LSVDYGKKSKLEFSI
326 YRGDVVPKDVNAAIA
336 NAAIAAIKTKRSIQF
352 DWCPTGFKVGINYQP
394 AWARLDHKFDLMYAK
401 KFDLMYAKRAFVHWY
60 FCETGAGKHVPRAVF

Function

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin

Protein Sequence

10 MRECISVHVG 20 QAGVQMGNAC 30 WELYCLEHGI 40 QPDGQMPSDK 50 TIGGGDDSFT 60 TFFCETGAGK 70 HVPRAVFVDL 80 EPTVIDEIRN 90 GPYRQLFHPE 100 QLITGKEDAA 110 NNYARGHYTI 120 GKEIIDPVLD 130 RIRKLSDQCT 140 GLQGFLVFHS 150 FGGGTGSGFT 160 SLLMERLSVD 170 YGKKSKLEFS 180 IYPAPQVSTA 190 VVEPYNSILT 200 THTTLEHSDC 210 AFMVDNEAIY 220 DICRRNLDIE 230 RPTYTNLNRL 240 ISQIVSSITA 250 SLRFDGALNV 260 DLTEFQTNLV 270 PYPRIHFPLA 280 TYAPVISAEK 290 AYHEQLSVAE 300 ITNACFEPAN 310 QMVKCDPRHG 320 KYMACCLLYR 330 GDVVPKDVNA 340 AIAAIKTKRS 350 IQFVDWCPTG 360 FKVGINYQPP 370 TVVPGGDLAK 380 VQRAVCMLSN 390 TTAIAEAWAR 400 LDHKFDLMYA 410 KRAFVHWYVG 420 EGMEEGEFSE 430 AREDMAALEK 440 DYEEVGIDSY EDEDEGEE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005929 cilium
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005874 microtubule
Cellular Component GO:0015630 microtubule cytoskeleton
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0016787 hydrolase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0030182 neuron differentiation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.