Search Results
Overview
| Uniprot ID | P68370 |
|---|---|
| Protein Name | Tubulin alpha-1A chain |
| Gene Name | Tuba1a |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 163 | RLSVDYGKKSKLEFS |
| 311 | KCDPRHGKYMACCLL |
| 326 | YRGDVVPKDVNAAIA |
| 336 | NAAIATIKTKRTIQF |
| 394 | AWARLDHKFDLMYAK |
| 401 | KFDLMYAKRAFVHWY |
| 60 | FSETGAGKHVPRAVF |
| 96 | PEQLITGKEDAANNY |
Function
Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (By similarity). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (By similarity). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (By similarity)
Protein Sequence
10
MRECISIHVG
20
QAGVQIGNAC
30
WELYCLEHGI
40
QPDGQMPSDK
50
TIGGGDDSFN
60
TFFSETGAGK
70
HVPRAVFVDL
80
EPTVIDEVRT
90
GTYRQLFHPE
100
QLITGKEDAA
110
NNYARGHYTI
120
GKEIIDLVLD
130
RIRKLADQCT
140
GLQGFLVFHS
150
FGGGTGSGFT
160
SLLMERLSVD
170
YGKKSKLEFS
180
IYPAPQVSTA
190
VVEPYNSILT
200
THTTLEHSDC
210
AFMVDNEAIY
220
DICRRNLDIE
230
RPTYTNLNRL
240
IGQIVSSITA
250
SLRFDGALNV
260
DLTEFQTNLV
270
PYPRIHFPLA
280
TYAPVISAEK
290
AYHEQLSVAE
300
ITNACFEPAN
310
QMVKCDPRHG
320
KYMACCLLYR
330
GDVVPKDVNA
340
AIATIKTKRT
350
IQFVDWCPTG
360
FKVGINYQPP
370
TVVPGGDLAK
380
VQRAVCMLSN
390
TTAIAEAWAR
400
LDHKFDLMYA
410
KRAFVHWYVG
420
EGMEEGEFSE
430
AREDMAALEK
440
DYEEVGVDSV
450
EGEGEEEGEE
Y
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005879 | axonemal microtubule |
| Cellular Component | GO:0005929 | cilium |
| Cellular Component | GO:0000793 | condensed chromosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005881 | cytoplasmic microtubule |
| Cellular Component | GO:0036464 | cytoplasmic ribonucleoprotein granule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Cellular Component | GO:0043209 | myelin sheath |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0055037 | recycling endosome |
| Cellular Component | GO:0036126 | sperm flagellum |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0016787 | hydrolase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Biological Process | GO:0006458 | 'de novo' protein folding |
| Biological Process | GO:0030534 | adult behavior |
| Biological Process | GO:0008344 | adult locomotory behavior |
| Biological Process | GO:0071277 | cellular response to calcium ion |
| Biological Process | GO:0007098 | centrosome cycle |
| Biological Process | GO:0021696 | cerebellar cortex morphogenesis |
| Biological Process | GO:0021987 | cerebral cortex development |
| Biological Process | GO:0021542 | dentate gyrus development |
| Biological Process | GO:0030317 | flagellated sperm motility |
| Biological Process | GO:0048853 | forebrain morphogenesis |
| Biological Process | GO:0010467 | gene expression |
| Biological Process | GO:0010001 | glial cell differentiation |
| Biological Process | GO:0021766 | hippocampus development |
| Biological Process | GO:0048873 | homeostasis of number of cells within a tissue |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0007626 | locomotory behavior |
| Biological Process | GO:0035641 | locomotory exploration behavior |
| Biological Process | GO:0007613 | memory |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0046785 | microtubule polymerization |
| Biological Process | GO:0007017 | microtubule-based process |
| Biological Process | GO:0000278 | mitotic cell cycle |
| Biological Process | GO:0061744 | motor behavior |
| Biological Process | GO:0022008 | neurogenesis |
| Biological Process | GO:0051402 | neuron apoptotic process |
| Biological Process | GO:0030182 | neuron differentiation |
| Biological Process | GO:0001764 | neuron migration |
| Biological Process | GO:0140058 | neuron projection arborization |
| Biological Process | GO:0072384 | organelle transport along microtubule |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0021859 | pyramidal neuron differentiation |
| Biological Process | GO:0050807 | regulation of synapse organization |
| Biological Process | GO:1902065 | response to L-glutamate |
| Biological Process | GO:0009612 | response to mechanical stimulus |
| Biological Process | GO:0034612 | response to tumor necrosis factor |
| Biological Process | GO:0007224 | smoothened signaling pathway |
| Biological Process | GO:0001964 | startle response |
| Biological Process | GO:0050808 | synapse organization |
| Biological Process | GO:0008542 | visual learning |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.