Search Results

Overview

Uniprot IDP68371
Protein NameTubulin beta-4B chain
Gene NameTUBB4B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
252 QLNADLRKLAVNMVP
324 FRGRMSMKEVDEQML
58 YNEATGGKYVPRAVL

Function

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin

Protein Sequence

10 MREIVHLQAG 20 QCGNQIGAKF 30 WEVISDEHGI 40 DPTGTYHGDS 50 DLQLERINVY 60 YNEATGGKYV 70 PRAVLVDLEP 80 GTMDSVRSGP 90 FGQIFRPDNF 100 VFGQSGAGNN 110 WAKGHYTEGA 120 ELVDSVLDVV 130 RKEAESCDCL 140 QGFQLTHSLG 150 GGTGSGMGTL 160 LISKIREEYP 170 DRIMNTFSVV 180 PSPKVSDTVV 190 EPYNATLSVH 200 QLVENTDETY 210 CIDNEALYDI 220 CFRTLKLTTP 230 TYGDLNHLVS 240 ATMSGVTTCL 250 RFPGQLNADL 260 RKLAVNMVPF 270 PRLHFFMPGF 280 APLTSRGSQQ 290 YRALTVPELT 300 QQMFDAKNMM 310 AACDPRHGRY 320 LTVAAVFRGR 330 MSMKEVDEQM 340 LNVQNKNSSY 350 FVEWIPNNVK 360 TAVCDIPPRG 370 LKMSATFIGN 380 STAIQELFKR 390 ISEQFTAMFR 400 RKAFLHWYTG 410 EGMDEMEFTE 420 AESNMNDLVS 430 EYQQYQDATA 440 EEEGEFEEEA EEEVA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005879 axonemal microtubule
Cellular Component GO:0035578 azurophil granule lumen
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:1903561 extracellular vesicle
Cellular Component GO:0045171 intercellular bridge
Cellular Component GO:0005874 microtubule
Cellular Component GO:0072686 mitotic spindle
Cellular Component GO:0005634 nucleus
Cellular Component GO:0036126 sperm flagellum
Molecular Function GO:0003725 double-stranded RNA binding
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0042288 MHC class I protein binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Molecular Function GO:0051082 unfolded protein binding
Biological Process GO:0030317 flagellated sperm motility
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0042267 natural killer cell mediated cytotoxicity

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.