Search Results
Overview
| Uniprot ID | P68372 |
|---|---|
| Protein Name | Tubulin beta-4B chain |
| Gene Name | Tubb4b |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 58 | YNEATGGKYVPRAVL |
Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin
Protein Sequence
10
MREIVHLQAG
20
QCGNQIGAKF
30
WEVISDEHGI
40
DPTGTYHGDS
50
DLQLERINVY
60
YNEATGGKYV
70
PRAVLVDLEP
80
GTMDSVRSGP
90
FGQIFRPDNF
100
VFGQSGAGNN
110
WAKGHYTEGA
120
ELVDSVLDVV
130
RKEAESCDCL
140
QGFQLTHSLG
150
GGTGSGMGTL
160
LISKIREEYP
170
DRIMNTFSVV
180
PSPKVSDTVV
190
EPYNATLSVH
200
QLVENTDETY
210
CIDNEALYDI
220
CFRTLKLTTP
230
TYGDLNHLVS
240
ATMSGVTTCL
250
RFPGQLNADL
260
RKLAVNMVPF
270
PRLHFFMPGF
280
APLTSRGSQQ
290
YRALTVPELT
300
QQMFDAKNMM
310
AACDPRHGRY
320
LTVAAVFRGR
330
MSMKEVDEQM
340
LNVQNKNSSY
350
FVEWIPNNVK
360
TAVCDIPPRG
370
LKMSATFIGN
380
STAIQELFKR
390
ISEQFTAMFR
400
RKAFLHWYTG
410
EGMDEMEFTE
420
AESNMNDLVS
430
EYQQYQDATA
440
EEEGEFEEEA
EEEVA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005879 | axonemal microtubule |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0045171 | intercellular bridge |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Cellular Component | GO:0072686 | mitotic spindle |
| Cellular Component | GO:0043209 | myelin sheath |
| Cellular Component | GO:0036126 | sperm flagellum |
| Cellular Component | GO:0045298 | tubulin complex |
| Molecular Function | GO:0003725 | double-stranded RNA binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Biological Process | GO:0030317 | flagellated sperm motility |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0007017 | microtubule-based process |
| Biological Process | GO:0000278 | mitotic cell cycle |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.