Search Results

Overview

Uniprot IDP68402
Protein NamePlatelet-activating factor acetylhydrolase IB subunit alpha2
Gene NamePAFAH1B2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
145 GLLPRGEKPNPLRQK
155 PLRQKNAKVNQLLKV
86 RHVLWRLKNGELENI

Function

Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE (By similarity). May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis (By similarity)

Protein Sequence

10 MSQGDSNPAA 20 IPHAAEDIQG 30 DDRWMSQHNR 40 FVLDCKDKEP 50 DVLFVGDSMV 60 QLMQQYEIWR 70 ELFSPLHALN 80 FGIGGDTTRH 90 VLWRLKNGEL 100 ENIKPKVIVV 110 WVGTNNHENT 120 AEEVAGGIEA 130 IVQLINTRQP 140 QAKIIVLGLL 150 PRGEKPNPLR 160 QKNAKVNQLL 170 KVSLPKLANV 180 QLLDTDGGFV 190 HSDGAISCHD 200 MFDFLHLTGG 210 GYAKICKPLH 220 ELIMQLLEET PEEKQTTIA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex
Biological Process GO:0007283 spermatogenesis
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:1904813 ficolin-1-rich granule lumen
Cellular Component GO:0034774 secretory granule lumen
Molecular Function GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity
Molecular Function GO:0047179 platelet-activating factor acetyltransferase activity
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0044877 protein-containing complex binding
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0062234 platelet activating factor catabolic process
Biological Process GO:0016239 positive regulation of macroautophagy

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.