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Overview

Uniprot IDP68511
Protein Name14-3-3 protein eta
Gene NameYwhah
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
110 LLDKFLIKNCNDFQY
142 AEVASGEKKNSVVEA
143 EVASGEKKNSVVEAS
162 KEAFEISKEHMQPTH
69 VISSIEQKTMADGNE
77 TMADGNEKKLEKVKA

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity)

Protein Sequence

10 MGDREQLLQR 20 ARLAEQAERY 30 DDMASAMKAV 40 TELNEPLSNE 50 DRNLLSVAYK 60 NVVGARRSSW 70 RVISSIEQKT 80 MADGNEKKLE 90 KVKAYREKIE 100 KELETVCNDV 110 LALLDKFLIK 120 NCNDFQYESK 130 VFYLKMKGDY 140 YRYLAEVASG 150 EKKNSVVEAS 160 EAAYKEAFEI 170 SKEHMQPTHP 180 IRLGLALNFS 190 VFYYEIQNAP 200 EQACLLAKQA 210 FDDAIAELDT 220 LNEDSYKDST 230 LIMQLLRDNL 240 TLWTSDQQDE EAGEGN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0150048 cerebellar granule cell to Purkinje cell synapse
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098793 presynapse
Cellular Component GO:0045202 synapse
Molecular Function GO:0003779 actin binding
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0035259 nuclear glucocorticoid receptor binding
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0017080 sodium channel regulator activity
Molecular Function GO:0044325 transmembrane transporter binding
Biological Process GO:0006713 glucocorticoid catabolic process
Biological Process GO:0008104 intracellular protein localization
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0086010 membrane depolarization during action potential
Biological Process GO:0050774 negative regulation of dendrite morphogenesis
Biological Process GO:0042921 nuclear receptor-mediated glucocorticoid signaling pathway
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0099171 presynaptic modulation of chemical synaptic transmission
Biological Process GO:0002028 regulation of sodium ion transport
Biological Process GO:0007165 signal transduction

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.