Search Results
Overview
| Uniprot ID | P68871 |
|---|---|
| Protein Name | Hemoglobin subunit beta |
| Gene Name | HBB |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 121 | VLAHHFGKEFTPPVQ |
| 133 | PVQAAYQKVVAGVAN |
| 145 | VANALAHKYH***** |
| 18 | AVTALWGKVNVDEVG |
| 60 | DAVMGNPKVKAHGKK |
| 66 | PKVKAHGKKVLGAFS |
| 67 | KVKAHGKKVLGAFSD |
| 83 | LAHLDNLKGTFATLS |
| 9 | VHLTPEEKSAVTALW |
| 96 | LSELHCDKLHVDPEN |
Function
Involved in oxygen transport from the lung to the various peripheral tissues
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0072562 | blood microparticle |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0071682 | endocytic vesicle lumen |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:1904813 | ficolin-1-rich granule lumen |
| Cellular Component | GO:0031838 | haptoglobin-hemoglobin complex |
| Cellular Component | GO:0005833 | hemoglobin complex |
| Cellular Component | GO:1904724 | tertiary granule lumen |
| Molecular Function | GO:0020037 | heme binding |
| Molecular Function | GO:0031721 | hemoglobin alpha binding |
| Molecular Function | GO:0030492 | hemoglobin binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0019825 | oxygen binding |
| Molecular Function | GO:0005344 | oxygen carrier activity |
| Biological Process | GO:0097746 | blood vessel diameter maintenance |
| Biological Process | GO:0015670 | carbon dioxide transport |
| Biological Process | GO:0098869 | cellular oxidant detoxification |
| Biological Process | GO:0048821 | erythrocyte development |
| Biological Process | GO:0042744 | hydrogen peroxide catabolic process |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0030185 | nitric oxide transport |
| Biological Process | GO:0015671 | oxygen transport |
| Biological Process | GO:0070527 | platelet aggregation |
| Biological Process | GO:0045429 | positive regulation of nitric oxide biosynthetic process |
| Biological Process | GO:0008217 | regulation of blood pressure |
| Biological Process | GO:0070293 | renal absorption |
| Biological Process | GO:0042542 | response to hydrogen peroxide |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.
[5] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.
[6] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[7] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.