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Overview

Uniprot IDP69736
Protein NameEndothelial differentiation-related factor 1
Gene NameEdf1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
14 DTVTVLRKKGPTAAQ
143 DIGKPIEKGPKAK**
25 TAAQAKSKQAILAAQ
43 EDVETSKKWAAGQNK
50 KWAAGQNKQHSITKN
56 NKQHSITKNTAKLDR

Function

Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. Might function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism (By similarity)

Protein Sequence

10 MAESDWDTVT 20 VLRKKGPTAA 30 QAKSKQAILA 40 AQRRGEDVET 50 SKKWAAGQNK 60 QHSITKNTAK 70 LDRETEELHH 80 DRVTLEVGKV 90 IQRGRQSKGL 100 TQKDLATKIN 110 EKPQVIADYE 120 SGRAIPNNQV 130 LGKIERAIGL 140 KLRGKDIGKP IEKGPKAK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0001094 TFIID-class transcription factor complex binding
Molecular Function GO:0003713 transcription coactivator activity
Biological Process GO:0030154 cell differentiation
Biological Process GO:0006351 DNA-templated transcription

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.