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Overview

Uniprot ID	P69897
Protein Name	Tubulin beta-5 chain
Gene Name	Tubb5
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
58	YNEATGGKYVPRAIL

Function

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin

Protein Sequence

10 MREIVHIQAG 20 QCGNQIGAKF 30 WEVISDEHGI 40 DPTGTYHGDS 50 DLQLDRISVY 60 YNEATGGKYV 70 PRAILVDLEP 80 GTMDSVRSGP 90 FGQIFRPDNF 100 VFGQSGAGNN 110 WAKGHYTEGA 120 ELVDSVLDVV 130 RKEAESCDCL 140 QGFQLTHSLG 150 GGTGSGMGTL 160 LISKIREEYP 170 DRIMNTFSVV 180 PSPKVSDTVV 190 EPYNATLSVH 200 QLVENTDETY 210 CIDNEALYDI 220 CFRTLKLTTP 230 TYGDLNHLVS 240 ATMSGVTTCL 250 RFPGQLNADL 260 RKLAVNMVPF 270 PRLHFFMPGF 280 APLTSRGSQQ 290 YRALTVPELT 300 QQVFDAKNMM 310 AACDPRHGRY 320 LTVAAVFRGR 330 MSMKEVDEQM 340 LNVQNKNSSY 350 FVEWIPNNVK 360 TAVCDIPPRG 370 LKMAVTFIGN 380 STAIQELFKR 390 ISEQFTAMFR 400 RKAFLHWYTG 410 EGMDEMEFTE 420 AESNMNDLVS 430 EYQQYQDATA 440 EEEEDFGEEA EEEA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0044297	cell body
Cellular Component	GO:0097542	ciliary tip
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule
Cellular Component	GO:0045171	intercellular bridge
Cellular Component	GO:0045121	membrane raft
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0015630	microtubule cytoskeleton
Cellular Component	GO:0072686	mitotic spindle
Cellular Component	GO:0005641	nuclear envelope lumen
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0032991	protein-containing complex
Cellular Component	GO:0097229	sperm end piece
Cellular Component	GO:0097228	sperm principal piece
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0032794	GTPase activating protein binding
Molecular Function	GO:0003924	GTPase activity
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0042288	MHC class I protein binding
Molecular Function	GO:0019904	protein domain specific binding
Molecular Function	GO:0044877	protein-containing complex binding
Molecular Function	GO:0005200	structural constituent of cytoskeleton
Molecular Function	GO:0031625	ubiquitin protein ligase binding
Biological Process	GO:0000226	microtubule cytoskeleton organization
Biological Process	GO:0007017	microtubule-based process
Biological Process	GO:0000278	mitotic cell cycle
Biological Process	GO:0071895	odontoblast differentiation
Biological Process	GO:0050807	regulation of synapse organization
Biological Process	GO:0051225	spindle assembly

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.