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Overview

Uniprot ID	P70404
Protein Name	Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial
Gene Name	Idh3g
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
159	PGVVTRHKDIDILIV
226	VHKANIMKLGDGLFL

Function

Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers

Protein Sequence

10 MALKVAIAAG 20 GAAKAMLKPT 30 LLCRPWEVLA 40 AHVAPRRSIS 50 SQQTIPPSAK 60 YGGRHTVTMI 70 PGDGIGPELM 80 LHVKSVFRHA 90 CVPVDFEEVH 100 VSSNADEEDI 110 RNAIMAIRRN 120 RVALKGNIET 130 NHNLPPSHKS 140 RNNILRTSLD 150 LYANVIHCKS 160 LPGVVTRHKD 170 IDILIVRENT 180 EGEYSSLEHE 190 SVAGVVESLK 200 IITKAKSLRI 210 AEYAFKLAQE 220 SGRKKVTAVH 230 KANIMKLGDG 240 LFLQCCREVA 250 AHYPQITFDS 260 MIVDNTTMQL 270 VSRPQQFDVM 280 VMPNLYGNIV 290 NNVCAGLVGG 300 PGLVAGANYG 310 HVYAVFETAT 320 RNTGKSIANK 330 NIANPTATLL 340 ASCMMLDHLK 350 LHSYATSIRK 360 AVLASMDNEN 370 MHTPDIGGQG 380 TTSQAIQDII 390 RHIRIINGRA VEA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0045242	isocitrate dehydrogenase complex (NAD+)
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0001917	photoreceptor inner segment
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0008047	enzyme activator activity
Molecular Function	GO:0004449	isocitrate dehydrogenase (NAD+) activity
Molecular Function	GO:0000287	magnesium ion binding
Molecular Function	GO:0051287	NAD binding
Biological Process	GO:0006102	isocitrate metabolic process
Biological Process	GO:0006099	tricarboxylic acid cycle

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.