Overview
| Uniprot ID | P70460 |
|---|
| Protein Name | Vasodilator-stimulated phosphoprotein |
|---|
| Gene Name | Vasp |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 236 |
AKLRKVSKQEEASGG |
| 316 |
STTLPRMKSSSSVTT |
Function
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation (By similarity)
Protein Sequence
10
MSETVICSSR
20
ATVMLYDDSN
30
KRWLPAGTGP
40
QAFSRVQIYH
50
NPTANSFRVV
60
GRKMQPDQQV
70
VINCAIIRGV
80
KYNQATPIFH
90
QWRDARQVWG
100
LNFGSKEDAI
110
QFATGMANAL
120
EALEGGGPPP
130
APAPPAWSAQ
140
NGPSPEELEQ
150
QKRQPEHMER
160
RVSNAGGPPA
170
PPAGGPPPPP
180
GPPPPPGPPP
190
PPGLPSSGVS
200
GAGHGAGAAP
210
PPAPPLPTAQ
220
GPNSGGSGAP
230
GLAAAIAGAK
240
LRKVSKQEEA
250
SGGPLAPKAE
260
NSRSTGGGLM
270
EEMNAMLARR
280
RKATQVGEKP
290
PKDESASEES
300
EARLPAQSEP
310
VRRPWEKNST
320
TLPRMKSSSS
330
VTTSEAHPST
340
PCSSDDSDLE
350
RVKQELLEEV
360
RKELQKMKEE
370
IIEVFVQELR
KRGSP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005923 |
bicellular tight junction |
| Cellular Component |
GO:0030054 |
cell junction |
| Cellular Component |
GO:0005856 |
cytoskeleton |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0030175 |
filopodium |
| Cellular Component |
GO:0031527 |
filopodium membrane |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0030027 |
lamellipodium |
| Cellular Component |
GO:0031258 |
lamellipodium membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0098794 |
postsynapse |
| Molecular Function |
GO:0003779 |
actin binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0005522 |
profilin binding |
| Molecular Function |
GO:0017124 |
SH3 domain binding |
| Biological Process |
GO:0030036 |
actin cytoskeleton organization |
| Biological Process |
GO:0030041 |
actin filament polymerization |
| Biological Process |
GO:0008154 |
actin polymerization or depolymerization |
| Biological Process |
GO:0007411 |
axon guidance |
| Biological Process |
GO:0046847 |
filopodium assembly |
| Biological Process |
GO:0001843 |
neural tube closure |
| Biological Process |
GO:0030838 |
positive regulation of actin filament polymerization |
| Biological Process |
GO:0051289 |
protein homotetramerization |
Reference
[1] Sung E, Sim H, Cho YC, Lee W, Bae JS et al.. Global Profiling of Lysine Acetylation and Lactylation in Kupffer Cells.. J Proteome Res 22(12):3683-3691. 2023 Dec 1. PMID: 37897433.