Search Results
Overview
| Uniprot ID | P70566 |
|---|---|
| Protein Name | Tropomodulin-2 |
| Gene Name | Tmod2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 101 | KGRVFIPKEKPVETR |
| 13 | QKGLEKYKNIDEDEL |
| 220 | PTLKEFAKALETNTH |
| 230 | ETNTHVRKFSLAATR |
Function
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity)
Protein Sequence
10
MALPFQKGLE
20
KYKNIDEDEL
30
LGKLSEEELK
40
QLENVLDDLD
50
PESATLPAGF
60
RQKDQTQKAA
70
TGPFDREHLL
80
MYLEKEALEQ
90
KDREDFVPFT
100
GEKKGRVFIP
110
KEKPVETRKE
120
EKVTLDPELE
130
EALASASDTE
140
LYDLAAVLGV
150
HNLLNNPKFD
160
EETTNGQGRK
170
GPVRNVVKGE
180
KAKPVFEEPP
190
NPTNVEASLQ
200
QMKANDPSLQ
210
EVNLNNIKNI
220
PIPTLKEFAK
230
ALETNTHVRK
240
FSLAATRSND
250
PVALAFAEML
260
KVNKTLKSLN
270
VESNFITGAG
280
ILALVEALRE
290
NDTLTEIKID
300
NQRQQLGTAV
310
EMEIAQMLEE
320
NSRILKFGYQ
330
FTKQGPRTRV
340
AAAITKNNDL
350
VRKKRVEGDR
R
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0030016 | myofibril |
| Cellular Component | GO:0005865 | striated muscle thin filament |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0005523 | tropomyosin binding |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0007611 | learning or memory |
| Biological Process | GO:0006936 | muscle contraction |
| Biological Process | GO:0030239 | myofibril assembly |
| Biological Process | GO:0007270 | neuron-neuron synaptic transmission |
| Biological Process | GO:0051694 | pointed-end actin filament capping |
| Biological Process | GO:0045745 | positive regulation of G protein-coupled receptor signaling pathway |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.