Search Results
Overview
| Uniprot ID | P70580 |
|---|---|
| Protein Name | Membrane-associated progesterone receptor component 1 |
| Gene Name | Pgrmc1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 169 | FKYHHVGKLLKEGEE |
Function
Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (By similarity). May be implicated in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) immunotoxicity (PubMed:9006096). Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0044297 | cell body |
| Cellular Component | GO:0012505 | endomembrane system |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0030868 | smooth endoplasmic reticulum membrane |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0020037 | heme binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0005496 | steroid binding |
| Biological Process | GO:0008306 | associative learning |
| Biological Process | GO:0007411 | axon guidance |
| Biological Process | GO:0006783 | heme biosynthetic process |
| Biological Process | GO:0007613 | memory |
| Biological Process | GO:0099563 | modification of synaptic structure |
| Biological Process | GO:1905809 | negative regulation of synapse organization |
| Biological Process | GO:0140077 | positive regulation of lipoprotein transport |
| Biological Process | GO:1903078 | positive regulation of protein localization to plasma membrane |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.