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Overview

Uniprot ID	P70587
Protein Name	Leucine-rich repeat-containing protein 7
Gene Name	Lrrc7
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
1265	KGEESCGKMPADWRQ
927	KGVIAISKSTERLSP
946	IKSNKFKKSQSIDEI

Function

Adapter protein that is required for correct postsynapse architecture and regulates postsynaptic plasticity through interactions with different partners (By similarity). Through its interaction with CACNA1C, it enhances trafficking of voltage-dependent L-type calcium channels to the dendritic cell membrane and increases channel postsynaptic clustering, thereby facilitating excitatory calcium signaling (By similarity). It also serves as a scaffold that brings CAMK2A and PPP1CA into close proximity, probably facilitating rapid dephosphorylation of CAMK2A by PPP1CA and influencing CAMK2A-mediated regulation of postsynaptic plasticity (By similarity). Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term synaptic depression (By similarity)

Protein Sequence

10 MTTKRKLIGR 20 LVPCRCFRGE 30 EEIISVLDYS 40 HCSLQQVPKE 50 VFNFERTLEE 60 LYLDANQIEE 70 LPKQLFNCQA 80 LRKLSIPDND 90 LSSLPTSIAS 100 LVNLKELDIS 110 KNGVQEFPEN 120 IKCCKCLTII 130 EASVNPISKL 140 PDGFTQLLNL 150 TQLYLNDAFL 160 EFLPANFGRL 170 VKLRILELRE 180 NHLKTLPKSM 190 HKLAQLERLD 200 LGNNEFSELP 210 EVLDQIQNLR 220 ELWMDNNALQ 230 VLPGSIGKLK 240 MLVYLDMSKN 250 RIETVDMDIS 260 GCEALEDLLL 270 SSNMLQQLPD 280 SIGLLKKLTT 290 LKVDDNQLTM 300 LPNTIGNLSL 310 LEEFDCSCNE 320 LESLPPTIGY 330 LHSLRTLAVD 340 ENFLPELPRE 350 IGSCKNVTVM 360 SLRSNKLEFL 370 PEEIGQMQRL 380 RVLNLSDNRL 390 KNLPFSFTKL 400 KELAALWLSD 410 NQSKALIPLQ 420 TEAHPETKQR 430 VLTNYMFPQQ 440 PRGDEDFQSD 450 SDSFNPTLWE 460 EQRQQRMTVA 470 FEFEDKKEDD 480 ESAGKVKALS 490 CQAPWDRGQR 500 GITLQPARLS 510 GDCCTPWARC 520 DQQIQDMPVP 530 QSDPQLAWGC 540 ISGLQQERSM 550 CAPLPVAAQS 560 TTLPSLSGRQ 570 VEINLKRYPT 580 PYPEDLKNMV 590 KSVQNLVGKP 600 SHGVRVENAN 610 PTANTEQTVK 620 EKFEHKWPVA 630 PKEITVEDSF 640 VHPANEMRIG 650 ELHPSLAETP 660 LYPPKLVLLG 670 KDKKESTDES 680 EVDKTHCLNN 690 SVSSGTYSDY 700 SPSQASSASS 710 NTRVKVGSLQ 720 PTTKDAVHNS 730 LWGNRIAPPF 740 PQPLDAKPLL 750 TQREAVPPGN 760 LPQRPDRLPM 770 SDAFPDNWTD 780 GSHYDNTGFV 790 SEEATGENAN 800 NNPLLSSKAR 810 SVPAHGRRPL 820 IRQERIVGVP 830 LELEQSTHRH 840 TPETEVPPSN 850 PWQNWTRTPS 860 PFEDRTAFPS 870 KLETTPTTSP 880 LPERKDHMKE 890 PTETPGPFSP 900 GVPWEYHDPT 910 PNRSLGNVFS 920 QIHCRPDSSK 930 GVIAISKSTE 940 RLSPLMKDIK 950 SNKFKKSQSI 960 DEIDVGTYKV 970 YNIPLENYAS 980 GSDHLGSHER 990 PDKFLGPEHG 1000 MSSMSRSQSV 1010 PMLDDEMLMY 1020 GSSKGPPQQK 1030 ASMTKKVYQF 1040 DQSFNPQGAV 1050 EVKAEKRIPP 1060 PFAHNSEYVQ 1070 QPGKNIAKDL 1080 VSPRAYRGYP 1090 PMEQMFSFSQ 1100 PSVNEDAMVN 1110 AQFASQGPRA 1120 GFLRRADSLA 1130 SSTEMAMFRR 1140 VSEPHELPPG 1150 DRYGRAAYRG 1160 GLEGQSSVSM 1170 TDPQFLKRNG 1180 RYEDEHPSYQ 1190 EVKAQAGSFP 1200 AKNLTQRRPL 1210 SARSYSTESY 1220 GASQTRPVSA 1230 RPTMAALLEK 1240 IPSDYNLGNY 1250 GDKTSDNSDI 1260 KTRPTPVKGE 1270 ESCGKMPADW 1280 RQQLLRHIEA 1290 RRLDRTPSQQ 1300 SNILDNGQED 1310 VSPSGQWNPY 1320 PLGRRDVPPD 1330 TITKKAGSHI 1340 QTLMGSQSLQ 1350 HRSREQQPYE 1360 GNINKVTIQQ 1370 FQSPLPIQIP 1380 SSQATRGPQP 1390 GRCLIQTKGQ 1400 RSMDGYPEQF 1410 CVRIEKNPGL 1420 GFSISGGISG 1430 QGNPFKPSDK 1440 GIFVTRVQPD 1450 GPASNLLQPG 1460 DKILQANGHS 1470 FVHMEHEKAV 1480 LLLKSFQNTV 1490 DLVIQRELTV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0015629	actin cytoskeleton
Cellular Component	GO:0005912	adherens junction
Cellular Component	GO:0043194	axon initial segment
Cellular Component	GO:0016323	basolateral plasma membrane
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0043197	dendritic spine
Cellular Component	GO:0030175	filopodium
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0014069	postsynaptic density
Cellular Component	GO:0098839	postsynaptic density membrane
Molecular Function	GO:0019901	protein kinase binding
Biological Process	GO:0098609	cell-cell adhesion
Biological Process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
Biological Process	GO:0098887	neurotransmitter receptor transport, endosome to postsynaptic membrane
Biological Process	GO:0010976	positive regulation of neuron projection development
Biological Process	GO:0043113	receptor clustering
Biological Process	GO:1901424	response to toluene

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.