Overview
| Uniprot ID | P70615 |
|---|
| Protein Name | Lamin-B1 |
|---|
| Gene Name | Lmnb1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 261 |
DAQVRLYKEELEQTY |
Function
Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively. Plays a role in sperm morphological development during late stages of spermiogenesis, particularly the anchoring of the sperm head to the tail (By similarity). Component of the LMNB1/SUN5/SEPT12 bridge that connects the sperm proximal centriole to the implantation fossa, the bridge functions to prevent detachment of the proximal centriole from the posterior nucleus during spermiogenesis (By similarity)
Protein Sequence
10
MATATPVQQR
20
AGSRASAPAT
30
PFSPTRLSRL
40
QEKEELRELN
50
DRLAVYIDKV
60
RSLETENSAL
70
QLQVTEREEV
80
RGRELTGLKA
90
LYETELADAR
100
RALDDTARER
110
AKLQIELGKF
120
KAEHDQLLLN
130
YAKKESDLSG
140
AQIKLREYEA
150
ALNSKDAALA
160
TALGDKKSLE
170
GDLEDLKDQI
180
AQLEASLSAA
190
KKQLADETLL
200
KVDLENRCQS
210
LTEDLEFRKN
220
MYEEEINETR
230
RKHETRLVEV
240
DSGRQIEYEY
250
KLAQALHEMR
260
EQHDAQVRLY
270
KEELEQTYHA
280
KLENARLSSE
290
MNTSTVNSAR
300
GGMMESRMRI
310
ESLSSQLSNL
320
QKDSRACLER
330
IQELEDMLAK
340
ERDNSRRMLS
350
DKEREMAEIR
360
DQMQQQLNDY
370
EQLLDVKLAL
380
DMEISAYRKL
390
LEGEEERLKL
400
SPSPSSRVTV
410
SRASSSRSVR
420
TTRGKRKRVD
430
VEESEASSSV
440
SISHSASATG
450
NVCIEEIDVD
460
GKFIRLKNTS
470
EQDQPMGGWE
480
MIRKIGDTSV
490
SYKYTSRYVL
500
KAGQTVTVWA
510
ANAGVTASPP
520
TDLIWKNQNS
530
WGTGEDVKVV
540
LKNSQGEEVA
550
QRSTVFKTTI
560
PEEEEEEEEE
570
PIGVPLEEER
580
FHQQGTPRAS
NKSCAIM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005638 |
lamin filament |
| Cellular Component |
GO:0005635 |
nuclear envelope |
| Cellular Component |
GO:0005637 |
nuclear inner membrane |
| Cellular Component |
GO:0005652 |
nuclear lamina |
| Cellular Component |
GO:0016363 |
nuclear matrix |
| Cellular Component |
GO:0031965 |
nuclear membrane |
| Cellular Component |
GO:0034399 |
nuclear periphery |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003690 |
double-stranded DNA binding |
| Molecular Function |
GO:0043274 |
phospholipase binding |
| Molecular Function |
GO:1990837 |
sequence-specific double-stranded DNA binding |
| Molecular Function |
GO:0005200 |
structural constituent of cytoskeleton |
| Molecular Function |
GO:0160123 |
structural constituent of nuclear lamina |
| Biological Process |
GO:1904613 |
cellular response to 2,3,7,8-tetrachlorodibenzodioxine |
| Biological Process |
GO:0071386 |
cellular response to corticosterone stimulus |
| Biological Process |
GO:1905232 |
cellular response to L-glutamate |
| Biological Process |
GO:0031507 |
heterochromatin formation |
| Biological Process |
GO:0022008 |
neurogenesis |
| Biological Process |
GO:0006998 |
nuclear envelope organization |
| Biological Process |
GO:0007097 |
nuclear migration |
| Biological Process |
GO:0051664 |
nuclear pore localization |
| Biological Process |
GO:0090435 |
protein localization to nuclear envelope |
| Biological Process |
GO:0009410 |
response to xenobiotic stimulus |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.