Search Results

Overview

Uniprot ID	P70670
Protein Name	Nascent polypeptide-associated complex subunit alpha, muscle-specific form
Gene Name	Naca
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
1306	STTPSPQKIPKVAGP
504	QAGLPTRKDTTLQPL
744	GPKGSLNKLSPTPPS
833	TSATAVPKDTSATLS
909	TPKSVSLKGAPAMTS

Function

Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres

Protein Sequence

10 MPGEATETVP 20 ATEQELPQPQ 30 AETAVLPMSS 40 ALKVAAVGQP 50 GPTPPSSLGP 60 QQSPIVTAHQ 70 PSPLPSSVSS 80 TPFEVPFAQP 90 ITAETALPSG 100 TAPPTPTFLP 110 HLIGPPISPA 120 ALALASPMIG 130 LAQKGARSSS 140 APLSLVALAP 150 HSVQKSSVCP 160 PHPLTSPPSA 170 AGAELGALTA 180 SIPPLEPKTS 190 TSQVPSQGTL 200 NLKGTAPCPP 210 DVVRAFPSHL 220 ENPLASVQPG 230 LMSCPQTLSN 240 TSPVKGVPIS 250 SALTQSRLSL 260 NLKGPVSPPA 270 RNTAAPSIPL 280 APSTSLGCHL 290 PLLHHSSVDS 300 PIQPPGQSGL 310 AVSNPTSVGH 320 SGIAASCPPE 330 RCVVPALPSR 340 LLAVDSGAAP 350 SDDKGSSAVT 360 NELCSPPGSS 370 NVAGTSLSPK 380 ASLVPKGSNV 390 ALQPLVTQVP 400 ASQKTGLKEI 410 PVSCIGATHH 420 ALDNPSAISV 430 APATHVPPPT 440 SSGLVSSKDP 450 ASPVTSLVVP 460 AAHKQFPAPP 470 ASATLGVPVS 480 PLPATEGLKN 490 LPISALVNVG 500 APVSPAQAGL 510 PTRKDTTLQP 520 LAPIALKESP 530 SSQSASSLEV 540 LSEDTVTKKT 550 TGGPAPVVRP 560 AIAGVATTTS 570 LRADSPPAVI 580 RADSCVSPNT 590 VSQPLKRSVT 600 DPAMAPRTAK 610 NTAPSTTSPL 620 VPLASEGCPV 630 ASSMALSPQN 640 ASVSETALAL 650 SPEIPKSVPF 660 PDPPLAEISF 670 SNARKVDAVS 680 HMESSGSSRQ 690 GHPDASVTAK 700 GTVVCLADSS 710 LDTSVSASKG 720 SALSGASSPL 730 YPLEVSFLPE 740 AGLAVQGPKG 750 SLNKLSPTPP 760 SSKGAPVPST 770 GAPPSPKGAP 780 IVPTESSISS 790 KQVPAEILPS 800 PQKTPEVTAS 810 RLISAVQSPK 820 VDPIMSDVTP 830 TSPKKTSATA 840 VPKDTSATLS 850 LKSVPAVTSL 860 SPPKAPVAPS 870 NEATIVPTEI 880 PTSLKNALAA 890 ATPKETLATS 900 IPKVTSPSPQ 910 KTPKSVSLKG 920 APAMTSKKAT 930 EIAASKDVSP 940 SQFPKEVPLL 950 PHVPPTSPPK 960 SPVSDTLSGA 970 LTSPPPKGPP 980 ATLAETPTYP 990 KKSPKPAASK 1000 KTPATPSPEG 1010 VTAVPLEIPP 1020 CSKKAPKTAA 1030 PKESSATSSS 1040 KRAPKTAVSK 1050 EIPSKGVTAV 1060 PLEISLPLKE 1070 TSKSATPGEK 1080 SASSPKRSPK 1090 TAGPKETPPG 1100 GVTAVPPEIS 1110 LPPKETPQNA 1120 TPNESLAASS 1130 QKRSPKTSVP 1140 KETPPGGVTA 1150 MPLEIPSAPQ 1160 KAPKTAVPKQ 1170 IPTPEDAVTI 1180 LAGSPLSPKK 1190 ASKTAAPKEA 1200 PATPSVGVIA 1210 VSGEISPSPK 1220 KTSKTAAPKE 1230 NSATLPPKRS 1240 PKTAAPKETP 1250 ATSSEGVTAV 1260 PSEISPSPPT 1270 PASKGVPVTL 1280 TPKGAPNALA 1290 ESPASPKKVP 1300 KTAAPEETST 1310 TPSPQKIPKV 1320 AGPKEASATP 1330 PSKKTPKTAV 1340 PKETSAPSEG 1350 VTAVPLEIPP 1360 SPRKAPKTAA 1370 PKETPAPSPE 1380 GATTAPVQIP 1390 PSPRKGSKKA 1400 GSKETPTTPS 1410 PEGVTAAPLE 1420 IPISSKKTSK 1430 MASPKETLVT 1440 PSSKKLSQTV 1450 GPKETSLEGA 1460 TAVPLEIPPS 1470 HKKAPKTVDP 1480 KQVPLTPSPK 1490 DAPTTLAESP 1500 SSPKKAPKTA 1510 APPSERVTTV 1520 PPEKPATPQK 1530 ASATTASKVP 1540 VPAETQEVAV 1550 SSRETPVTPA 1560 VPPVKNPSSH 1570 KKTSKTIELK 1580 EAPATLPPSP 1590 TKSPKIPSSK 1600 KAPRTSAPKE 1610 FPASPSIKPV 1620 TTSLAQTAPP 1630 SLQKAPSTTI 1640 PKENLAAPAV 1650 LPVSSKSPAA 1660 PAAASASLSP 1670 ATAAPQTAPK 1680 EATTIPSCKK 1690 AAATETPIET 1700 STAPSLEGAP 1710 KETSETSVSK 1720 VLMSSPPKKA 1730 SSSKRASTLP 1740 ATTLPSLKEA 1750 SVLSPTATSS 1760 GKDSHISPVS 1770 DACSTGTTTP 1780 QASEKLPSKK 1790 GPTAFTEMLA 1800 APAPESALAI 1810 TAPIQKSPGA 1820 NSNSASSPKC 1830 PDPSSKKDTK 1840 GLPSAVALAP 1850 QTVPVEKDTS 1860 KAIETLLVSP 1870 AKGSDCLHSP 1880 KGPVGSQVAT 1890 PLAAFTSDKV 1900 PPEAVSASVA 1910 PKPAPAASLT 1920 LAPSPVAPLP 1930 PKQPLLESAP 1940 GSVLESPSKL 1950 PVPAEEDELP 1960 PLIPPEAVSG 1970 GEPFQPILVN 1980 MPAPKPAGTP 1990 APAPSAKQPV 2000 LKNNKGSGTE 2010 SDSDESVPEL 2020 EEQDSTQTAT 2030 QQAQLAAAAE 2040 IDEEPVSKAK 2050 QSRSEKKARK 2060 AMSKLGLRQV 2070 TGVTRVTIRK 2080 SKNILFVITK 2090 PDVYKSPASD 2100 TYIVFGEAKI 2110 EDLSQQAQLA 2120 AAEKFKVQGE 2130 AVSNIQENTQ 2140 TPTVQEESEE 2150 EEVDETGVEV 2160 KDIELVMSQA 2170 NVSRAKAVRA 2180 LKNNSNDIVN AIMELTM

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005854	nascent polypeptide-associated complex
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0017025	TBP-class protein binding
Molecular Function	GO:0003713	transcription coactivator activity
Molecular Function	GO:0051082	unfolded protein binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0051451	myoblast migration
Biological Process	GO:1905551	negative regulation of protein localization to endoplasmic reticulum
Biological Process	GO:0006612	protein targeting to membrane

Reference

[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.