Search Results
Overview
| Uniprot ID | P70705 |
|---|---|
| Protein Name | Copper-transporting ATPase 1 |
| Gene Name | Atp7a |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 246 | KKQPKYLKLGAIDVE |
Function
ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (By similarity). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (By similarity). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (By similarity). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (By similarity). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity)
Protein Sequence
10
MEPNMDANSI
20
TITVEGMTCI
30
SCVRTIEQQI
40
GKVNGVHHIK
50
VSLEEKSATV
60
IYNPKLQTPK
70
TLQEAIDDMG
80
FDALLHNANP
90
LPVLTNTVFL
100
TVTAPLALPW
110
DHIQSTLLKT
120
KGVTGVKISP
130
QQRSAVVTII
140
PSVVSANQIV
150
ELVPDLSLDM
160
GTQEKKSGTS
170
EEHSTPQAGE
180
VLLKMRVEGM
190
TCHSCTSTIE
200
GKVGKLQGVQ
210
RIKVSLDNQE
220
ATIVYQPHLI
230
TAEEIKKQIE
240
AVGFPAFIKK
250
QPKYLKLGAI
260
DVERLKSTPV
270
KSSEGSQQKS
280
PAYPSDSAIT
290
FTIDGMHCKS
300
CVSNIESALS
310
TLQYVSSIVV
320
SLENRSAIVK
330
YNASLVTPEI
340
LRKAIEAVSP
350
GQYRVSISSE
360
VESPTSSPSS
370
SSLQKMPLNL
380
VSQPLTQEVV
390
ININGMTCNS
400
CVQSIEGVIS
410
KKPGVKSIHV
420
SLTNSTGTIE
430
YDPLLTSPEP
440
LREAIEDMGF
450
DAVLPADMKE
460
PLVVIAQPSL
470
ETPLLPSTTE
480
PENVMTPVQN
490
KCYIQVSGMT
500
CASCVANIER
510
NLRREEGIYS
520
VLVALMAGKA
530
EVRYNPAVIQ
540
PRVIAELIRE
550
LGFGAVVMEN
560
AGEGNGILEL
570
VVRGMTCASC
580
VHKIESTLTK
590
HKGIFYCSVA
600
LATNKAHIKY
610
DPEIIGPRDI
620
IHTIGNLGFE
630
ASLVKKDRSA
640
NHLDHKREIK
650
QWRGSFLVSL
660
FFCIPVMGLM
670
IYMMVMDHHL
680
ATLNHNQNMS
690
NEEMINMHSS
700
MFLERQILPG
710
LSIMNLLSLL
720
LCLPVQFCGG
730
WYFYIQAYKA
740
LRHKTANMDV
750
LIVLATTIAF
760
AYSLVILLVA
770
MYERAKVNPI
780
TFFDTPPMLF
790
VFIALGRWLE
800
HIAKGKTSEA
810
LAKLISLQAT
820
EATIVTLNSE
830
NLLLSEEQVD
840
VELVQRGDII
850
KVVPGGKFPV
860
DGRVIEGHSM
870
VDESLITGEA
880
MPVAKKPGST
890
VIAGSINQNG
900
SLLIRATHVG
910
ADTTLSQIVK
920
LVEEAQTSKA
930
PIQQFADKLS
940
GYFVPFIVLV
950
SIVTLLVWII
960
IGFQNFEIVE
970
AYFPGYNRSI
980
SRTETIIRFA
990
FQASITVLCI
1000
ACPCSLGLAT
1010
PTAVMVGTGV
1020
GAQNGILIKG
1030
GEPLEMAHKV
1040
KVVVFDKTGT
1050
ITHGTPVVNQ
1060
VKVLVESNKI
1070
SRNKILAIVG
1080
TAESNSEHPL
1090
GAAVTKYCKQ
1100
ELDTETLGTC
1110
TDFQVVPGCG
1120
ISCKVTNIEG
1130
LLHKSNLKIE
1140
ENNIKNASLV
1150
QIDAINEQSS
1160
PSSSMIIDAH
1170
LSNAVNTQQY
1180
KVLIGNREWM
1190
IRNGLVISND
1200
VDESMIEHER
1210
RGRTAVLVTI
1220
DDELCGLIAI
1230
ADTVKPEAEL
1240
AVHILKSMGL
1250
EVVLMTGDNS
1260
KTARSIASQV
1270
GITKVFAEVL
1280
PSHKVAKVKQ
1290
LQEEGKRVAM
1300
VGDGINDSPA
1310
LAMASVGIAI
1320
GTGTDVAIEA
1330
ADVVLIRNDL
1340
LDVVASIDLS
1350
RKTVKRIRIN
1360
FVFALIYNLI
1370
GIPIAAGVFL
1380
PIGLVLQPWM
1390
GSAAMAASSV
1400
SVVLSSLFLK
1410
LYRKPTYDNY
1420
ELRPRSHTGQ
1430
RSPSEISVHV
1440
GIDDTSRNSP
1450
RLGLLDRIVN
1460
YSRASINSLL
1470
SDKRSLNSVV
1480
TSEPDKHSLL
1490
VGDFREDDDT
TL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0031526 | brush border membrane |
| Cellular Component | GO:0031252 | cell leading edge |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0031901 | early endosome membrane |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0005770 | late endosome |
| Cellular Component | GO:0033162 | melanosome membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005902 | microvillus |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0030141 | secretory granule |
| Cellular Component | GO:0005802 | trans-Golgi network |
| Cellular Component | GO:0032588 | trans-Golgi network membrane |
| Cellular Component | GO:0030140 | trans-Golgi network transport vesicle |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0005507 | copper ion binding |
| Molecular Function | GO:0005375 | copper ion transmembrane transporter activity |
| Molecular Function | GO:0032767 | copper-dependent protein binding |
| Molecular Function | GO:1903136 | cuprous ion binding |
| Molecular Function | GO:0043682 | P-type divalent copper transporter activity |
| Molecular Function | GO:0140581 | P-type monovalent copper transporter activity |
| Molecular Function | GO:0031267 | small GTPase binding |
| Molecular Function | GO:0016532 | superoxide dismutase copper chaperone activity |
| Biological Process | GO:0046034 | ATP metabolic process |
| Biological Process | GO:0001568 | blood vessel development |
| Biological Process | GO:0001974 | blood vessel remodeling |
| Biological Process | GO:0051216 | cartilage development |
| Biological Process | GO:0006584 | catecholamine metabolic process |
| Biological Process | GO:0071230 | cellular response to amino acid stimulus |
| Biological Process | GO:0071236 | cellular response to antibiotic |
| Biological Process | GO:0071276 | cellular response to cadmium ion |
| Biological Process | GO:0071279 | cellular response to cobalt ion |
| Biological Process | GO:0071280 | cellular response to copper ion |
| Biological Process | GO:0071456 | cellular response to hypoxia |
| Biological Process | GO:0071281 | cellular response to iron ion |
| Biological Process | GO:0071284 | cellular response to lead ion |
| Biological Process | GO:0036120 | cellular response to platelet-derived growth factor stimulus |
| Biological Process | GO:0021954 | central nervous system neuron development |
| Biological Process | GO:0021702 | cerebellar Purkinje cell differentiation |
| Biological Process | GO:0030199 | collagen fibril organization |
| Biological Process | GO:0060003 | copper ion export |
| Biological Process | GO:0015677 | copper ion import |
| Biological Process | GO:0006825 | copper ion transport |
| Biological Process | GO:0048813 | dendrite morphogenesis |
| Biological Process | GO:0010273 | detoxification of copper ion |
| Biological Process | GO:0042417 | dopamine metabolic process |
| Biological Process | GO:0048251 | elastic fiber assembly |
| Biological Process | GO:0042414 | epinephrine metabolic process |
| Biological Process | GO:0030198 | extracellular matrix organization |
| Biological Process | GO:0007565 | female pregnancy |
| Biological Process | GO:0009101 | glycoprotein biosynthetic process |
| Biological Process | GO:0031069 | hair follicle morphogenesis |
| Biological Process | GO:0001701 | in utero embryonic development |
| Biological Process | GO:0006878 | intracellular copper ion homeostasis |
| Biological Process | GO:0006568 | L-tryptophan metabolic process |
| Biological Process | GO:0007595 | lactation |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0007626 | locomotory behavior |
| Biological Process | GO:0048286 | lung alveolus development |
| Biological Process | GO:0007005 | mitochondrion organization |
| Biological Process | GO:0034760 | negative regulation of iron ion transmembrane transport |
| Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
| Biological Process | GO:0048812 | neuron projection morphogenesis |
| Biological Process | GO:0042421 | norepinephrine biosynthetic process |
| Biological Process | GO:0042415 | norepinephrine metabolic process |
| Biological Process | GO:0018205 | peptidyl-lysine modification |
| Biological Process | GO:0043473 | pigmentation |
| Biological Process | GO:0043085 | positive regulation of catalytic activity |
| Biological Process | GO:0045793 | positive regulation of cell size |
| Biological Process | GO:1904960 | positive regulation of cytochrome-c oxidase activity |
| Biological Process | GO:0050679 | positive regulation of epithelial cell proliferation |
| Biological Process | GO:0010592 | positive regulation of lamellipodium assembly |
| Biological Process | GO:0048023 | positive regulation of melanin biosynthetic process |
| Biological Process | GO:1903036 | positive regulation of response to wounding |
| Biological Process | GO:1901671 | positive regulation of superoxide dismutase activity |
| Biological Process | GO:1904754 | positive regulation of vascular associated smooth muscle cell migration |
| Biological Process | GO:0021860 | pyramidal neuron development |
| Biological Process | GO:1904959 | regulation of cytochrome-c oxidase activity |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:0002082 | regulation of oxidative phosphorylation |
| Biological Process | GO:0001836 | release of cytochrome c from mitochondria |
| Biological Process | GO:0019430 | removal of superoxide radicals |
| Biological Process | GO:0046688 | response to copper ion |
| Biological Process | GO:0010041 | response to iron(III) ion |
| Biological Process | GO:0010288 | response to lead ion |
| Biological Process | GO:0010042 | response to manganese ion |
| Biological Process | GO:0010043 | response to zinc ion |
| Biological Process | GO:0042428 | serotonin metabolic process |
| Biological Process | GO:0043588 | skin development |
| Biological Process | GO:0042093 | T-helper cell differentiation |
| Biological Process | GO:0006570 | tyrosine metabolic process |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.