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Overview

Uniprot IDP78310
Protein NameCoxsackievirus and adenovirus receptor
Gene NameCXADR
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
235 NVVPPSNKAGLIAGA

Function

Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair

Protein Sequence

10 MALLLCFVLL 20 CGVVDFARSL 30 SITTPEEMIE 40 KAKGETAYLP 50 CKFTLSPEDQ 60 GPLDIEWLIS 70 PADNQKVDQV 80 IILYSGDKIY 90 DDYYPDLKGR 100 VHFTSNDLKS 110 GDASINVTNL 120 QLSDIGTYQC 130 KVKKAPGVAN 140 KKIHLVVLVK 150 PSGARCYVDG 160 SEEIGSDFKI 170 KCEPKEGSLP 180 LQYEWQKLSD 190 SQKMPTSWLA 200 EMTSSVISVK 210 NASSEYSGTY 220 SCTVRNRVGS 230 DQCLLRLNVV 240 PPSNKAGLIA 250 GAIIGTLLAL 260 ALIGLIIFCC 270 RKKRREEKYE 280 KEVHHDIRED 290 VPPPKSRTST 300 ARSYIGSNHS 310 SLGSMSPSNM 320 EGYSKTQYNQ 330 VPSEDFERTP 340 QSPTLPPAKV 350 AAPNLSRMGA 360 IPVMIPAQSK DGSIV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0001669 acrosomal vesicle
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0016327 apicolateral plasma membrane
Cellular Component GO:0005923 bicellular tight junction
Cellular Component GO:0044297 cell body
Cellular Component GO:0030054 cell junction
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0030175 filopodium
Cellular Component GO:0030426 growth cone
Cellular Component GO:0014704 intercalated disc
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0031594 neuromuscular junction
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0008013 beta-catenin binding
Molecular Function GO:0050839 cell adhesion molecule binding
Molecular Function GO:0086082 cell adhesive protein binding involved in AV node cell-bundle of His cell communication
Molecular Function GO:0071253 connexin binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0005178 integrin binding
Molecular Function GO:0030165 PDZ domain binding
Molecular Function GO:0005102 signaling receptor binding
Molecular Function GO:0001618 virus receptor activity
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0086067 AV node cell to bundle of His cell communication
Biological Process GO:0086072 AV node cell-bundle of His cell adhesion involved in cell communication
Biological Process GO:0055013 cardiac muscle cell development
Biological Process GO:0045216 cell-cell junction organization
Biological Process GO:0051607 defense response to virus
Biological Process GO:0010669 epithelial structure maintenance
Biological Process GO:0046629 gamma-delta T cell activation
Biological Process GO:0008354 germ cell migration
Biological Process GO:0007507 heart development
Biological Process GO:0007157 heterophilic cell-cell adhesion
Biological Process GO:0034109 homotypic cell-cell adhesion
Biological Process GO:0007005 mitochondrion organization
Biological Process GO:0030593 neutrophil chemotaxis
Biological Process GO:0098904 regulation of AV node cell action potential
Biological Process GO:0070633 transepithelial transport

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.