Search Results

Overview

Uniprot IDP78316
Protein NameNucleolar protein 14
Gene NameNOP14
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
199 LIEELIAKSKQEKRE
201 EELIAKSKQEKRERQ
235 IQTLLSHKTPKSENR
238 LLSHKTPKSENRDKK
26 GARGGPAKANSNPFE
334 DRRLLSYKDGKMNVE
35 NSNPFEVKVNRQKFQ
40 EVKVNRQKFQILGRK
405 EQRQTPGKGLISGKE
416 SGKERAGKATRDELP
809 GAVREIRKDNQFLAR

Function

Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity)

Protein Sequence

10 MAKAKKVGAR 20 RKASGAPAGA 30 RGGPAKANSN 40 PFEVKVNRQK 50 FQILGRKTRH 60 DVGLPGVSRA 70 RALRKRTQTL 80 LKEYKERDKS 90 NVFRDKRFGE 100 YNSNMSPEEK 110 MMKRFALEQQ 120 RHHEKKSIYN 130 LNEDEELTHY 140 GQSLADIEKH 150 NDIVDSDSDA 160 EDRGTLSAEL 170 TAAHFGGGGG 180 LLHKKTQQEG 190 EEREKPKSRK 200 ELIEELIAKS 210 KQEKRERQAQ 220 REDALELTEK 230 LDQDWKEIQT 240 LLSHKTPKSE 250 NRDKKEKPKP 260 DAYDMMVREL 270 GFEMKAQPSN 280 RMKTEAELAK 290 EEQEHLRKLE 300 AERLRRMLGK 310 DEDENVKKPK 320 HMSADDLNDG 330 FVLDKDDRRL 340 LSYKDGKMNV 350 EEDVQEEQSK 360 EASDPESNEE 370 EGDSSGGEDT 380 EESDSPDSHL 390 DLESNVESEE 400 ENEKPAKEQR 410 QTPGKGLISG 420 KERAGKATRD 430 ELPYTFAAPE 440 SYEELRSLLL 450 GRSMEEQLLV 460 VERIQKCNHP 470 SLAEGNKAKL 480 EKLFGFLLEY 490 VGDLATDDPP 500 DLTVIDKLVV 510 HLYHLCQMFP 520 ESASDAIKFV 530 LRDAMHEMEE 540 MIETKGRAAL 550 PGLDVLIYLK 560 ITGLLFPTSD 570 FWHPVVTPAL 580 VCLSQLLTKC 590 PILSLQDVVK 600 GLFVCCLFLE 610 YVALSQRFIP 620 ELINFLLGIL 630 YIATPNKASQ 640 GSTLVHPFRA 650 LGKNSELLVV 660 SAREDVATWQ 670 QSSLSLRWAS 680 RLRAPTSTEA 690 NHIRLSCLAV 700 GLALLKRCVL 710 MYGSLPSFHA 720 IMGPLQALLT 730 DHLADCSHPQ 740 ELQELCQSTL 750 TEMESQKQLC 760 RPLTCEKSKP 770 VPLKLFTPRL 780 VKVLEFGRKQ 790 GSSKEEQERK 800 RLIHKHKREF 810 KGAVREIRKD 820 NQFLARMQLS 830 EIMERDAERK 840 RKVKQLFNSL 850 ATQEGEWKAL KRKKFKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030686 90S preribosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0030692 Noc4p-Nop14p complex
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0032040 small-subunit processome
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0030515 snoRNA binding
Biological Process GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:0030490 maturation of SSU-rRNA
Biological Process GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:0042274 ribosomal small subunit biogenesis
Biological Process GO:0006364 rRNA processing

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.