Search Results

Overview

Uniprot IDP78344
Protein NameEukaryotic translation initiation factor 4 gamma 2
Gene NameEIF4G2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
158 AEGQPGQKQSTTFRR
288 MCSLMLSKELPARIR
31 GAPQHYPKTAGNSEF
41 GNSEFLGKTPGQNAQ
431 EMGGKFMKSQGLSQL
464 MPPRFSKKGQLNADE
484 AQSFLMNKNQVPKLQ
49 TPGQNAQKWIPARST
520 QTPQLGLKTNPPLIQ
532 LIQEKPAKTSKKPPP
535 EKPAKTSKKPPPSKE

Function

Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases

Protein Sequence

10 MESAIAEGGA 20 SRFSASSGGG 30 GSRGAPQHYP 40 KTAGNSEFLG 50 KTPGQNAQKW 60 IPARSTRRDD 70 NSAANNSANE 80 KERHDAIFRK 90 VRGILNKLTP 100 EKFDKLCLEL 110 LNVGVESKLI 120 LKGVILLIVD 130 KALEEPKYSS 140 LYAQLCLRLA 150 EDAPNFDGPA 160 AEGQPGQKQS 170 TTFRRLLISK 180 LQDEFENRTR 190 NVDVYDKREN 200 PLLPEEEEQR 210 AIAKIKMLGN 220 IKFIGELGKL 230 DLIHESILHK 240 CIKTLLEKKK 250 RVQLKDMGED 260 LECLCQIMRT 270 VGPRLDHERA 280 KSLMDQYFAR 290 MCSLMLSKEL 300 PARIRFLLQD 310 TVELREHHWV 320 PRKAFLDNGP 330 KTINQIRQDA 340 VKDLGVFIPA 350 PMAQGMRSDF 360 FLEGPFMPPR 370 MKMDRDPLGG 380 LADMFGQMPG 390 SGIGTGPGVI 400 QDRFSPTMGR 410 HRSNQLFNGH 420 GGHIMPPTQS 430 QFGEMGGKFM 440 KSQGLSQLYH 450 NQSQGLLSQL 460 QGQSKDMPPR 470 FSKKGQLNAD 480 EISLRPAQSF 490 LMNKNQVPKL 500 QPQITMIPPS 510 AQPPRTQTPP 520 LGQTPQLGLK 530 TNPPLIQEKP 540 AKTSKKPPPS 550 KEELLKLTET 560 VVTEYLNSGN 570 ANEAVNGVRE 580 MRAPKHFLPE 590 MLSKVIILSL 600 DRSDEDKEKA 610 SSLISLLKQE 620 GIATSDNFMQ 630 AFLNVLDQCP 640 KLEVDIPLVK 650 SYLAQFAARA 660 IISELVSISE 670 LAQPLESGTH 680 FPLFLLCLQQ 690 LAKLQDREWL 700 TELFQQSKVN 710 MQKMLPEIDQ 720 NKDRMLEILE 730 GKGLSFLFPL 740 LKLEKELLKQ 750 IKLDPSPQTI 760 YKWIKDNISP 770 KLHVDKGFVN 780 ILMTSFLQYI 790 SSEVNPPSDE 800 TDSSSAPSKE 810 QLEQEKQLLL 820 SFKPVMQKFL 830 HDHVDLQVSA 840 LYALQVHCYN 850 SNFPKGMLLR 860 FFVHFYDMEI 870 IEEEAFLAWK 880 EDITQEFPGK 890 GKALFQVNQW 900 LTWLETAEEE ESEEEAD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016281 eukaryotic translation initiation factor 4F complex
Cellular Component GO:0016020 membrane
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008135 translation factor activity, RNA binding
Molecular Function GO:0003743 translation initiation factor activity
Biological Process GO:0008219 cell death
Biological Process GO:0010507 negative regulation of autophagy
Biological Process GO:0030307 positive regulation of cell growth
Biological Process GO:0051726 regulation of cell cycle
Biological Process GO:0006446 regulation of translational initiation
Biological Process GO:0006413 translational initiation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.