Search Results

Overview

Uniprot IDP78345
Protein NameRibonuclease P protein subunit p38
Gene NameRPP38
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
262 TLQPLKIKKLIPNPN
263 LQPLKIKKLIPNPNK

Function

Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:10444065, PubMed:30454648, PubMed:9037013, PubMed:9630247). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465)

Protein Sequence

10 MAAAPQAPGR 20 GSLRKTRPLV 30 VKTSLNNPYI 40 IRWSALESED 50 MHFILQTLED 60 RLKAIGLQKI 70 EDKKKKNKTP 80 FLKKESREKC 90 SIAVDISENL 100 KEKKTDAKQQ 110 VSGWTPAHVR 120 KQLAIGVNEV 130 TRALERRELL 140 LVLVCKSVKP 150 AMITSHLIQL 160 SLSRSVPACQ 170 VPRLSERIAP 180 VIGLKCVLAL 190 AFKKNTTDFV 200 DEVRAIIPRV 210 PSLSVPWLQD 220 RIEDSGENLE 230 TEPLESQDRE 240 LLDTSFEDLS 250 KPKRKLADGR 260 QASVTLQPLK 270 IKKLIPNPNK 280 IRKPPKSKKA TPK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0001650 fibrillar center
Cellular Component GO:0030681 multimeric ribonuclease P complex
Cellular Component GO:0005655 nucleolar ribonuclease P complex
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000172 ribonuclease MRP complex
Molecular Function GO:0033204 ribonuclease P RNA binding
Biological Process GO:0006396 RNA processing
Biological Process GO:0006364 rRNA processing
Biological Process GO:0001682 tRNA 5'-leader removal

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.