Search Results

Overview

Uniprot IDP78346
Protein NameRibonuclease P protein subunit p30
Gene NameRPP30
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
246 FGIISTVKKPRPSEG
247 GIISTVKKPRPSEGD
262 EDCLPASKKAKCEG*
263 DCLPASKKAKCEG**

Function

Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:30454648, PubMed:9037013, PubMed:9630247). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465)

Protein Sequence

10 MAVFADLDLR 20 AGSDLKALRG 30 LVETAAHLGY 40 SVVAINHIVD 50 FKEKKQEIEK 60 PVAVSELFTT 70 LPIVQGKSRP 80 IKILTRLTII 90 VSDPSHCNVL 100 RATSSRARLY 110 DVVAVFPKTE 120 KLFHIACTHL 130 DVDLVCITVT 140 EKLPFYFKRP 150 PINVAIDRGL 160 AFELVYSPAI 170 KDSTMRRYTI 180 SSALNLMQIC 190 KGKNVIISSA 200 AERPLEIRGP 210 YDVANLGLLF 220 GLSESDAKAA 230 VSTNCRAALL 240 HGETRKTAFG 250 IISTVKKPRP 260 SEGDEDCLPA SKKAKCEG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030681 multimeric ribonuclease P complex
Cellular Component GO:0000172 ribonuclease MRP complex
Molecular Function GO:0004526 ribonuclease P activity
Molecular Function GO:0033204 ribonuclease P RNA binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006396 RNA processing
Biological Process GO:0006364 rRNA processing
Biological Process GO:0001682 tRNA 5'-leader removal
Biological Process GO:0008033 tRNA processing
Cellular Component GO:0005655 nucleolar ribonuclease P complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.