Overview
| Uniprot ID | P78368 |
|---|
| Protein Name | Casein kinase I isoform gamma-2 |
|---|
| Gene Name | CSNK1G2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 51 |
PNFRVGKKIGCGNFG |
Function
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation (PubMed:15077195, PubMed:15917222, PubMed:18794808, PubMed:19005213). Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate (By similarity). Involved in regulation of reactive oxygen species (ROS) levels (PubMed:37099597)
Protein Sequence
10
MDFDKKGGKG
20
ETEEGRRMSK
30
AGGGRSSHGI
40
RSSGTSSGVL
50
MVGPNFRVGK
60
KIGCGNFGEL
70
RLGKNLYTNE
80
YVAIKLEPIK
90
SRAPQLHLEY
100
RFYKQLSATE
110
GVPQVYYFGP
120
CGKYNAMVLE
130
LLGPSLEDLF
140
DLCDRTFTLK
150
TVLMIAIQLI
160
TRMEYVHTKS
170
LIYRDVKPEN
180
FLVGRPGTKR
190
QHAIHIIDFG
200
LAKEYIDPET
210
KKHIPYREHK
220
SLTGTARYMS
230
INTHLGKEQS
240
RRDDLEALGH
250
MFMYFLRGSL
260
PWQGLKADTL
270
KERYQKIGDT
280
KRATPIEVLC
290
ENFPEEMATY
300
LRYVRRLDFF
310
EKPDYDYLRK
320
LFTDLFDRSG
330
FVFDYEYDWA
340
GKPLPTPIGT
350
VHTDLPSQPQ
360
LRDKTQPHSK
370
NQALNSTNGE
380
LNADDPTAGH
390
SNAPITAPAE
400
VEVADETKCC
410
CFFKRRKRKS
LQRHK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005938 |
cell cortex |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0106310 |
protein serine kinase activity |
| Molecular Function |
GO:0004674 |
protein serine/threonine kinase activity |
| Biological Process |
GO:0006897 |
endocytosis |
| Biological Process |
GO:0090263 |
positive regulation of canonical Wnt signaling pathway |
| Biological Process |
GO:0006468 |
protein phosphorylation |
| Biological Process |
GO:0007165 |
signal transduction |
| Biological Process |
GO:0030148 |
sphingolipid biosynthetic process |
| Biological Process |
GO:0016055 |
Wnt signaling pathway |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.