Search Results
Overview
| Uniprot ID | P78386 |
|---|---|
| Protein Name | Keratin, type II cuticular Hb5 |
| Gene Name | KRT85 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 229 | ENEFVVLKKDVDCAY |
| 230 | NEFVVLKKDVDCAYL |
Function
Structural component of intermediate filaments in the hair follicle (PubMed:16525032). As a type II hair keratin, participates in the formation of keratin intermediate filament networks by forming obligate heterodimers with type I hair keratins (PubMed:16525032). Expressed at early stages of hair differentiation in matrix cells and later in cuticle-forming cells, where it contributes to the structural integrity and mechanical resilience of the hair shaft (PubMed:16525032)
Protein Sequence
10
MSCRSYRISS
20
GCGVTRNFSS
30
CSAVAPKTGN
40
RCCISAAPYR
50
GVSCYRGLTG
60
FGSRSLCNLG
70
SCGPRIAVGG
80
FRAGSCGRSF
90
GYRSGGVCGP
100
SPPCITTVSV
110
NESLLTPLNL
120
EIDPNAQCVK
130
QEEKEQIKSL
140
NSRFAAFIDK
150
VRFLEQQNKL
160
LETKWQFYQN
170
QRCCESNLEP
180
LFSGYIETLR
190
REAECVEADS
200
GRLASELNHV
210
QEVLEGYKKK
220
YEEEVALRAT
230
AENEFVVLKK
240
DVDCAYLRKS
250
DLEANVEALV
260
EESSFLRRLY
270
EEEIRVLQAH
280
ISDTSVIVKM
290
DNSRDLNMDC
300
IIAEIKAQYD
310
DVASRSRAEA
320
ESWYRSKCEE
330
MKATVIRHGE
340
TLRRTKEEIN
350
ELNRMIQRLT
360
AEIENAKCQR
370
AKLEAAVAEA
380
EQQGEAALSD
390
ARCKLAELEG
400
ALQKAKQDMA
410
CLLKEYQEVM
420
NSKLGLDIEI
430
ATYRRLLEGE
440
EHRLCEGVGS
450
VNVCVSSSRG
460
GVSCGGLSYS
470
TTPGRQITSG
480
PSAIGGSITV
490
VAPDSCAPCQ
500
PRSSSFSCGS
SRSVRFA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0045095 | keratin filament |
| Molecular Function | GO:0030280 | structural constituent of skin epidermis |
| Molecular Function | GO:0005198 | structural molecule activity |
| Biological Process | GO:0008544 | epidermis development |
| Biological Process | GO:0045109 | intermediate filament organization |
| Biological Process | GO:0031424 | keratinization |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.