Overview
| Uniprot ID | P78411 |
|---|
| Protein Name | Iroquois-class homeodomain protein IRX-5 |
|---|
| Gene Name | IRX5 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 154 |
IMLAIITKMTLTQVS |
Function
Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12
Protein Sequence
10
MSYPQGYLYQ
20
PSASLALYSC
30
PAYSTSVISG
40
PRTDELGRSS
50
SGSAFSPYAG
60
STAFTAPSPG
70
YNSHLQYGAD
80
PAAAAAAAFS
90
SYVGSPYDHT
100
PGMAGSLGYH
110
PYAAPLGSYP
120
YGDPAYRKNA
130
TRDATATLKA
140
WLNEHRKNPY
150
PTKGEKIMLA
160
IITKMTLTQV
170
STWFANARRR
180
LKKENKMTWT
190
PRNRSEDEEE
200
EENIDLEKND
210
EDEPQKPEDK
220
GDPEGPEAGG
230
AEQKAASGCE
240
RLQGPPTPAG
250
KETEGSLSDS
260
DFKEPPSEGR
270
LDALQGPPRT
280
GGPSPAGPAA
290
ARLAEDPAPH
300
YPAGAPAPGP
310
HPAAGEVPPG
320
PGGPSVIHSP
330
PPPPPPAVLA
340
KPKLWSLAEI
350
ATSSDKVKDG
360
GGGNEGSPCP
370
PCPGPIAGQA
380
LGGSRASPAP
390
APSRSPSAQC
400
PFPGGTVLSR
410
PLYYTAPFYP
420
GYTNYGSFGH
430
LHGHPGPGPG
440
PTTGPGSHFN
450
GLNQTVLNRA
460
DALAKDPKML
470
RSQSQLDLCK
480
DSPYELKKGM
SDI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function |
GO:0000978 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function |
GO:1990837 |
sequence-specific double-stranded DNA binding |
| Molecular Function |
GO:0005499 |
vitamin D binding |
| Biological Process |
GO:0048468 |
cell development |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0048701 |
embryonic cranial skeleton morphogenesis |
| Biological Process |
GO:0008406 |
gonad development |
| Biological Process |
GO:0030182 |
neuron differentiation |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0007601 |
visual perception |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.