Search Results
Overview
| Uniprot ID | P78562 |
|---|---|
| Protein Name | Phosphate-regulating neutral endopeptidase PHEX |
| Gene Name | PHEX |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 13 | GSSVETGKKANRGTR |
| 14 | SSVETGKKANRGTRI |
Function
Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity (PubMed:15664000, PubMed:18162525, PubMed:18597632, PubMed:9593714). Cleaves ASARM peptides between Ser and Glu or Asp residues (PubMed:18597632). Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide (PubMed:18597632). Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides (PubMed:18162525, PubMed:18597632). Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation (PubMed:12220505)
Protein Sequence
10
MEAETGSSVE
20
TGKKANRGTR
30
IALVVFVGGT
40
LVLGTILFLV
50
SQGLLSLQAK
60
QEYCLKPECI
70
EAAAAILSKV
80
NLSVDPCDNF
90
FRFACDGWIS
100
NNPIPEDMPS
110
YGVYPWLRHN
120
VDLKLKELLE
130
KSISRRRDTE
140
AIQKAKILYS
150
SCMNEKAIEK
160
ADAKPLLHIL
170
RHSPFRWPVL
180
ESNIGPEGVW
190
SERKFSLLQT
200
LATFRGQYSN
210
SVFIRLYVSP
220
DDKASNEHIL
230
KLDQATLSLA
240
VREDYLDNST
250
EAKSYRDALY
260
KFMVDTAVLL
270
GANSSRAEHD
280
MKSVLRLEIK
290
IAEIMIPHEN
300
RTSEAMYNKM
310
NISELSAMIP
320
QFDWLGYIKK
330
VIDTRLYPHL
340
KDISPSENVV
350
VRVPQYFKDL
360
FRILGSERKK
370
TIANYLVWRM
380
VYSRIPNLSR
390
RFQYRWLEFS
400
RVIQGTTTLL
410
PQWDKCVNFI
420
ESALPYVVGK
430
MFVDVYFQED
440
KKEMMEELVE
450
GVRWAFIDML
460
EKENEWMDAG
470
TKRKAKEKAR
480
AVLAKVGYPE
490
FIMNDTHVNE
500
DLKAIKFSEA
510
DYFGNVLQTR
520
KYLAQSDFFW
530
LRKAVPKTEW
540
FTNPTTVNAF
550
YSASTNQIRF
560
PAGELQKPFF
570
WGTEYPRSLS
580
YGAIGVIVGH
590
EFTHGFDNNG
600
RKYDKNGNLD
610
PWWSTESEEK
620
FKEKTKCMIN
630
QYSNYYWKKA
640
GLNVKGKRTL
650
GENIADNGGL
660
REAFRAYRKW
670
INDRRQGLEE
680
PLLPGITFTN
690
NQLFFLSYAH
700
VRCNSYRPEA
710
AREQVQIGAH
720
SPPQFRVNGA
730
ISNFEEFQKA
740
FNCPPNSTMN
RGMDSCRLW
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0004222 | metalloendopeptidase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0031214 | biomineral tissue development |
| Biological Process | GO:0060348 | bone development |
| Biological Process | GO:0007267 | cell-cell signaling |
| Biological Process | GO:0071374 | cellular response to parathyroid hormone stimulus |
| Biological Process | GO:0071305 | cellular response to vitamin D |
| Biological Process | GO:0030324 | lung development |
| Biological Process | GO:0036211 | protein modification process |
| Biological Process | GO:0016485 | protein processing |
| Biological Process | GO:0006508 | proteolysis |
| Biological Process | GO:0060416 | response to growth hormone |
| Biological Process | GO:1990418 | response to insulin-like growth factor stimulus |
| Biological Process | GO:1904383 | response to sodium phosphate |
| Biological Process | GO:0001501 | skeletal system development |
Reference
PMID: N/A