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Overview

Uniprot IDP79307
Protein NameAmyloid-beta precursor protein
Gene NameAPP
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
106 KRSRKQCKTHTHIVI
134 LLVPDKCKFLHQERM
60 ESDPSGTKTCIGTKE

Function

Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP (By similarity). Inhibits G(o)-alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapses in axons (By similarity). May be involved in copper homeostasis/oxidative stress through copper ion reduction (By similarity). In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation (By similarity). Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 (By similarity)

Protein Sequence

10 MLPGLALVLL 20 AAWTARALEV 30 PTDGNAGLLA 40 EPQVAMFCGK 50 LNMHMNVQNG 60 KWESDPSGTK 70 TCIGTKEGIL 80 QYCQEVYPEL 90 QITNVVEANQ 100 PVTIQNWCKR 110 SRKQCKTHTH 120 IVIPYRCLVG 130 EFVSDALLVP 140 DKCKFLHQER 150 MDVCETHLHW 160 HTVAKETCSE 170 KSTNLHDYGM 180 LLPCGIDKFR 190 GVEFVCCPLA 200 EESDNIDSAD 210 AEEDDSDVWW 220 GGADTDYADG 230 SEDKVVEVAE 240 EEEVADVEEE 250 EAEDDEDDED 260 GDEVEEEAEE 270 PYEEATERTT 280 SIATTTTTTT 290 ESVEEVVREV 300 CSEQAETGPC 310 RAMISRWYFD 320 VTEGKCAPFF 330 YGGCGGNRNN 340 FDTEEYCMAV 350 CGSVMSQSLL 360 KTTQEHLPQD 370 PVKLPTTAAS 380 TPDAVDKYLE 390 TPGDENEHAH 400 FQKAKERLEA 410 KHRERMSQVM 420 REWEEAERQA 430 KNLPKADKKA 440 VIQHFQEKVE 450 SLEQEAANER 460 QQLVETHMAR 470 VEAMLNDRRR 480 LALENYITAL 490 QAVPPRPRHV 500 FNMLKKYVRA 510 EQKDRQHTLK 520 HFEHVRMVDP 530 KKAAQIRSQV 540 MTHLRVIYER 550 MNQSLSLLYN 560 VPAVAEEIQD 570 EVDELLQKEQ 580 NYSDDVLANM 590 ISEPRISYGN 600 DALMPSLTET 610 KTTVELLPVN 620 GEFSLDDLQP 630 WHPFGVDSVP 640 ANTENEVEPV 650 DARPAADRGL 660 TTRPGSGLTN 670 IKTEEISEVK 680 MDAEFRHDSG 690 YEVHHQKLVF 700 FAEDVGSNKG 710 AIIGLMVGGV 720 VIATVIVITL 730 VMLKKKQYTS 740 IHHGVVEVDA 750 AVTPEERHLS 760 KMQQNGYENP 770 TYKFFEQMQN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0005798 Golgi-associated vesicle
Cellular Component GO:0030426 growth cone
Cellular Component GO:0016020 membrane
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0005634 nucleus
Cellular Component GO:0043204 perikaryon
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0055037 recycling endosome
Cellular Component GO:0099503 secretory vesicle
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0008201 heparin binding
Molecular Function GO:0004867 serine-type endopeptidase inhibitor activity
Molecular Function GO:0030546 signaling receptor activator activity
Molecular Function GO:0005102 signaling receptor binding
Molecular Function GO:0046914 transition metal ion binding
Biological Process GO:0008344 adult locomotory behavior
Biological Process GO:0006915 apoptotic process
Biological Process GO:0008088 axo-dendritic transport
Biological Process GO:0016199 axon midline choice point recognition
Biological Process GO:0007409 axonogenesis
Biological Process GO:0007155 cell adhesion
Biological Process GO:0007417 central nervous system development
Biological Process GO:0050890 cognition
Biological Process GO:0048669 collateral sprouting in absence of injury
Biological Process GO:0016358 dendrite development
Biological Process GO:0006897 endocytosis
Biological Process GO:0030198 extracellular matrix organization
Biological Process GO:0006878 intracellular copper ion homeostasis
Biological Process GO:0035235 ionotropic glutamate receptor signaling pathway
Biological Process GO:0007626 locomotory behavior
Biological Process GO:0007617 mating behavior
Biological Process GO:0031175 neuron projection development
Biological Process GO:0016322 neuron remodeling
Biological Process GO:0007219 Notch signaling pathway
Biological Process GO:0010604 positive regulation of macromolecule metabolic process
Biological Process GO:0045931 positive regulation of mitotic cell cycle
Biological Process GO:0040014 regulation of multicellular organism growth
Biological Process GO:0050803 regulation of synapse structure or activity
Biological Process GO:0006417 regulation of translation
Biological Process GO:0008542 visual learning
Cellular Component GO:0009986 cell surface
Cellular Component GO:0005905 clathrin-coated pit
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005769 early endosome
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005576 extracellular region

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.