Overview
| Uniprot ID | P79335 |
|---|
| Protein Name | Plasminogen activator inhibitor 1 |
|---|
| Gene Name | SERPINE1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 51 |
RQVVQASKDRNVVFS |
Function
Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence (By similarity). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity)
Protein Sequence
10
MRMSLVFACL
20
AMGLALTFAE
30
GSASSHHQSL
40
AARLATDFGV
50
KVFRQVVQAS
60
KDRNVVFSPY
70
GVASVLAMLQ
80
LTTAGDTQQQ
90
IQEAMQFKIE
100
EKGMAPALRQ
110
LYKELMGPWN
120
KDEISTADAI
130
FVQRDLKLVQ
140
GFMPYFFRLF
150
RTTVKQVDFS
160
EMDRARFIIN
170
DWVKRHTKGM
180
INDLLGQGAV
190
DQLTRLVLVN
200
ALYFNGQWKT
210
PFPEKSTHHR
220
LFHKSDGSTV
230
SVPMMAQTNK
240
FNYTEFSTPD
250
GHYYDILELP
260
YHGNTLSMFI
270
AAPYEKEVPL
280
SALTSILDAQ
290
LISQWKGNMT
300
RLTRLLVLPK
310
FSLESEVDLR
320
RPLENLGMTD
330
MFRPNQADFS
340
SLSDQELLYM
350
SQALQKVKIE
360
VNESGTVASS
370
STAIIVSARM
380
APEEIIMDRP
390
FLFVVRHNPT
400
GTVLFMGQVM
EP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005615 |
extracellular space |
| Molecular Function |
GO:0004867 |
serine-type endopeptidase inhibitor activity |
| Biological Process |
GO:0030195 |
negative regulation of blood coagulation |
| Biological Process |
GO:0010757 |
negative regulation of plasminogen activation |
| Biological Process |
GO:0061044 |
negative regulation of vascular wound healing |
| Biological Process |
GO:0050820 |
positive regulation of coagulation |
| Biological Process |
GO:0090399 |
replicative senescence |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.