Search Results

Overview

Uniprot IDP79403
Protein NameNeutral alpha-glucosidase AB
Gene NameGANAB
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
269 HADSLRLKVTEGGDP
39 AVDRSNFKTCEESSF
462 HLASKRRKLVAIVDP
48 CEESSFCKRQRSIRP
491 QNLGLYVKTRDGSDY
899 VVIIGAGKPATVVLQ
908 ATVVLQTKGSPESRL

Function

Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia

Protein Sequence

10 MAAVAAVAAR 20 RRRSWTGLVL 30 ACLGVCLGLT 40 LAVDRSNFKT 50 CEESSFCKRQ 60 RSIRPGQSPY 70 RALLDSLQLG 80 PDTLTIHLIN 90 EVTKVLLVLE 100 LQGLQKNMTR 110 IRIDELEPRR 120 PRYRVPDVLV 130 AEPPTARLSV 140 SGQDDNSVEV 150 TVAEGPYKII 160 LTARPFRLDL 170 LEDRSLLLSV 180 NARGLLNFEH 190 QRAPRVSQGS 200 KDPAEGDGAQ 210 PEEAPGDGDK 220 PEEIQGKAEK 230 DEPGAWEETF 240 KTHSDSKPYG 250 PTSVGLDFSL 260 PGMEHVYGIP 270 EHADSLRLKV 280 TEGGDPYRLY 290 NLDVFQYELY 300 NPMALYGSVP 310 VLLAHSPHRD 320 LGIFWLNAAE 330 TWVDISSNTA 340 GKTLFGKMLD 350 YLQGSGETPQ 360 TDVRWMSESG 370 IIDVFLLLGP 380 SVFDVFRQYA 390 SLTGTQALPP 400 LFSLGYHQSR 410 WNYRDEADVL 420 EVNQGFDDHN 430 LPCDFIWLDI 440 EHADGKRYFT 450 WDPSRFPQPR 460 TMLEHLASKR 470 RKLVAIVDPH 480 IKVDSSYRVH 490 EELQNLGLYV 500 KTRDGSDYEG 510 WCWPGAASYP 520 DFTNPKMRAW 530 WADMFRFENY 540 EGSSSNLYVW 550 NDMNEPSVFN 560 GPEVTMLKDA 570 QHYGGWEHRD 580 LHNIYGFYVH 590 MATADGLVLR 600 SGGVERPFVL 610 SRAFFAGSQR 620 FGAVWTGDNT 630 AEWDHLKISI 640 PMCLSLGLVG 650 VSFCGADVGG 660 FFKNPEPELL 670 VRWYQMGAYQ 680 PFFRAHAHLD 690 TGRREPWLLP 700 TQYQDMIRDA 710 LGQRYSLLPF 720 WYTLFYQAHR 730 EGVPVMRALW 740 VHYPQDVTTF 750 SIDDEFLLGD 760 ALLVHPVTDS 770 EAHGVQVYLP 780 GQGEVWYDVH 790 SYQKYHGPQT 800 LYLPVTLSSI 810 PVFQRGGTIV 820 PRWMRVRRSS 830 DCMKDDPITL 840 FVALSPQGTA 850 QGELFLDDGH 860 TFNYQTGHEF 870 LLRRFSFSGN 880 TLVSSSADSK 890 GHFETPVWIE 900 RVVIIGAGKP 910 ATVVLQTKGS 920 PESRLSFQHD 930 PETSVLILRK 940 PGVNVASDWS IHLR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0017177 glucosidase II complex
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0043231 intracellular membrane-bounded organelle
Cellular Component GO:0042470 melanosome
Molecular Function GO:0090599 alpha-glucosidase activity
Molecular Function GO:0030246 carbohydrate binding
Molecular Function GO:0106407 Glc2Man9GlcNAc2 oligosaccharide glucosidase activity
Molecular Function GO:0033919 glucan 1,3-alpha-glucosidase activity
Biological Process GO:0005975 carbohydrate metabolic process
Biological Process GO:0006491 N-glycan processing

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.