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Overview

Uniprot IDP80021
Protein NameATP synthase F(1) complex subunit alpha, mitochondrial
Gene NameATP5F1A
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
126 FGNDKLIKEGDIVKR
132 IKEGDIVKRTGAIVD
161 LGNAIDGKGPIGSKT
167 GKGPIGSKTRRRVGL
175 TRRRVGLKAPGIIPR
218 IGDRQTGKTSIAIDT
230 IDTIINQKRFNDGTD
239 FNDGTDEKKKLYCIY
261 STVAQLVKRLTDADA
305 EYFRDNGKHALIIYD
316 IIYDDLSKQAVAYRQ
498 GVRGYLDKLEPSKIT
525 QHQALLGKIRADGKI
531 GKIRADGKISEETDA
539 ISEETDAKLKEIVTN

Function

Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity)

Protein Sequence

10 MLSVRVAAAV 20 ARALPRRAGL 30 VSKNALGSSF 40 VAARNLHASN 50 TRLQKTGTAE 60 VSSILEERIL 70 GADTSVDLEE 80 TGRVLSIGDG 90 IARVHGLRNV 100 QAEEMVEFSS 110 GLKGMSLNLE 120 PDNVGVVVFG 130 NDKLIKEGDI 140 VKRTGAIVDV 150 PVGEELLGRV 160 VDALGNAIDG 170 KGPIGSKTRR 180 RVGLKAPGII 190 PRISVREPMQ 200 TGIKAVDSLV 210 PIGRGQRELI 220 IGDRQTGKTS 230 IAIDTIINQK 240 RFNDGTDEKK 250 KLYCIYVAIG 260 QKRSTVAQLV 270 KRLTDADAMK 280 YTIVVSATAS 290 DAAPLQYLAP 300 YSGCSMGEYF 310 RDNGKHALII 320 YDDLSKQAVA 330 YRQMSLLLRR 340 PPGREAYPGD 350 VFYLHSRLLE 360 RAAKMNDAFG 370 GGSLTALPVI 380 ETQAGDVSAY 390 IPTNVISITD 400 GQIFLETELF 410 YKGIRPAINV 420 GLSVSRVGSA 430 AQTRAMKQVA 440 GTMKLELAQY 450 REVAAFAQFG 460 SDLDAATQQL 470 LSRGVRLTEL 480 LKQGQYAPMA 490 IEEQVAVIYA 500 GVRGYLDKLE 510 PSKITKFENA 520 FLSHVISQHQ 530 ALLGKIRADG 540 KISEETDAKL 550 KEIVTNFLAG FEA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0045259 proton-transporting ATP synthase complex
Molecular Function GO:0043531 ADP binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
Biological Process GO:0015986 proton motive force-driven ATP synthesis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.