Search Results
Overview
| Uniprot ID | P80031 |
|---|---|
| Protein Name | Glutathione S-transferase P |
| Gene Name | GSTP1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 113 | YTNYEAGKEKYVKEL |
| 79 | RSFGLYGKDQKEAAL |
Function
Catalyzes conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Acts as a negative regulator of ferroptosis by mediating glutathione conjugation and detoxification of 4-hydroxynonenal (4-HNE) reactive aldehyde. Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration
Protein Sequence
10
PPYTITYFPV
20
RGRCEAMRML
30
LADQDQSWKE
40
EVVTMETWPP
50
LKPSCLFRQL
60
PKFQDGDLTL
70
YQSNAILRHL
80
GRSFGLYGKD
90
QKEAALVDMV
100
NDGVEDLRCK
110
YATLIYTNYE
120
AGKEKYVKEL
130
PEHLKPFETL
140
LSQNQGGQAF
150
VVGSQISFAD
160
YNLLDLLRIH
170
QVLNPSCLDA
180
FPLLSAYVAR
190
LSARPKIKAF
200
LASPEHVNRP
INGNGKN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0004364 | glutathione transferase activity |
| Biological Process | GO:1901687 | glutathione derivative biosynthetic process |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0051122 | hepoxilin biosynthetic process |
| Biological Process | GO:0110076 | negative regulation of ferroptosis |
| Biological Process | GO:0006693 | prostaglandin metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.