Search Results
Overview
| Uniprot ID | P80254 |
|---|---|
| Protein Name | D-dopachrome decarboxylase |
| Gene Name | Ddt |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 110 | LEPWQIGKKGTVMTF |
| 33 | ATATILDKPEDRVSV |
Function
Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI)
Protein Sequence
10
MPFVELETNL
20
PASRIPAGLE
30
NRLCAATATI
40
LDKPEDRVSV
50
TIRPGMTLLM
60
NKSTEPCAHL
70
LISSIGVVGT
80
AEQNRSHSSS
90
FFKFLTEELS
100
LDQDRIIIRF
110
FPLEPWQIGK
KGTVMTFL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0005126 | cytokine receptor binding |
| Molecular Function | GO:0033981 | D-dopachrome decarboxylase activity |
| Molecular Function | GO:0004167 | dopachrome isomerase activity |
| Molecular Function | GO:0050178 | phenylpyruvate tautomerase activity |
| Molecular Function | GO:0002020 | protease binding |
| Biological Process | GO:0042438 | melanin biosynthetic process |
| Biological Process | GO:0010760 | negative regulation of macrophage chemotaxis |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0050729 | positive regulation of inflammatory response |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.