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Overview

Uniprot IDP80272
Protein NameNon-histone chromosomal protein HMG-17
Gene NameHMGN2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
18 KGDKAKVKDEPQRRS
31 RSARLSAKPAPPKPE
64 KGKADAGKDGNNPAE
82 AKTDQAQKAEGAGDA

Function

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity)

Protein Sequence

10 MPKRKAEGDA 20 KGDKAKVKDE 30 PQRRSARLSA 40 KPAPPKPEPK 50 PKKAPAKKGE 60 KVPKGKKGKA 70 DAGKDGNNPA 80 ENGDAKTDQA 90 QKAEGAGDAK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0031492 nucleosomal DNA binding
Biological Process GO:0006325 chromatin organization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.