Overview
| Uniprot ID | P80276 |
|---|
| Protein Name | Aldo-keto reductase family 1 member B1 |
|---|
| Gene Name | AKR1B1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 169 |
FNHLQVEKILNKPGL |
| 173 |
QVEKILNKPGLKYKP |
| 201 |
EKLIEYCKSKGIVVT |
| 240 |
RIKAIAAKYNKTTAQ |
| 243 |
AIAAKYNKTTAQVLI |
| 263 |
RNLIVIPKSVTPERI |
| 27 |
TWKSPPGKVTEAVKV |
| 69 |
KLQGQVVKREDLFIV |
| 86 |
LWCTDHEKNLVKGAC |
| 90 |
DHEKNLVKGACQTTL |
Function
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides, bile acids and xenobiotics substrates. It catalyzes the reduction of glucose to sorbitol, the first step of the polyol pathway, an alternative route of glucose metabolism that converts glucose to fructose. This pathway becomes highly active under elevated glucose levels, such as during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls)
Protein Sequence
10
MASHLVLYTG
20
AKMPILGLGT
30
WKSPPGKVTE
40
AVKVAIDLGY
50
RHIDCAHVYQ
60
NENEVGLGLQ
70
EKLQGQVVKR
80
EDLFIVSKLW
90
CTDHEKNLVK
100
GACQTTLRDL
110
KLDYLDLYLI
120
HWPTGFKPGK
130
DPFPLDGDGN
140
VVPDESDFVE
150
TWEAMEELVD
160
EGLVKAIGVS
170
NFNHLQVEKI
180
LNKPGLKYKP
190
AVNQIEVHPY
200
LTQEKLIEYC
210
KSKGIVVTAY
220
SPLGSPDRPW
230
AKPEDPSLLE
240
DPRIKAIAAK
250
YNKTTAQVLI
260
RFPMQRNLIV
270
IPKSVTPERI
280
AENFQVFDFE
290
LSPEDMNTLL
300
SYNRNWRVCA
310
LMSCASHKDY
PFHEEY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Molecular Function |
GO:0004032 |
aldose reductase (NADPH) activity |
| Molecular Function |
GO:0052650 |
all-trans-retinol dehydrogenase (NADP+) activity |
| Molecular Function |
GO:0047655 |
allyl-alcohol dehydrogenase activity |
| Molecular Function |
GO:0047956 |
glycerol dehydrogenase (NADP+) activity |
| Molecular Function |
GO:0036130 |
prostaglandin H2 endoperoxidase reductase activity |
| Molecular Function |
GO:0001758 |
retinal dehydrogenase (NAD+) activity |
| Biological Process |
GO:0001523 |
retinoid metabolic process |
| Biological Process |
GO:0006060 |
sorbitol metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.