Search Results
Overview
| Uniprot ID | P80297 |
|---|---|
| Protein Name | Metallothionein-1X |
| Gene Name | MT1X |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 51 | CAQGCICKGTSDKCS |
| 56 | ICKGTSDKCSCCA** |
Function
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. May be involved in FAM168A anti-apoptotic signaling (PubMed:23251525)
Protein Sequence
10
MDPNCSCSPV
20
GSCACAGSCK
30
CKECKCTSCK
40
KSCCSCCPVG
50
CAKCAQGCIC
60
KGTSDKCSCC
A
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0071276 | cellular response to cadmium ion |
| Biological Process | GO:0071280 | cellular response to copper ion |
| Biological Process | GO:0036018 | cellular response to erythropoietin |
| Biological Process | GO:0071294 | cellular response to zinc ion |
| Biological Process | GO:0010273 | detoxification of copper ion |
| Biological Process | GO:0006882 | intracellular zinc ion homeostasis |
| Biological Process | GO:0045926 | negative regulation of growth |
| Biological Process | GO:0010038 | response to metal ion |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.