Overview
| Uniprot ID | P80365 |
|---|
| Protein Name | 11-beta-hydroxysteroid dehydrogenase type 2 |
|---|
| Gene Name | HSD11B2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 256 |
ELLPWGVKVSIIQPG |
Function
Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as cortisol, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as cortisone, in the presence of NAD(+) (PubMed:10497248, PubMed:12788846, PubMed:17314322, PubMed:22796344, PubMed:23685396, PubMed:27927697, PubMed:30902677, PubMed:33387577, PubMed:7859916, PubMed:8538347). Functions as a dehydrogenase (oxidase), thereby decreasing the concentration of active glucocorticoids, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids (PubMed:10497248, PubMed:12788846, PubMed:17314322, PubMed:33387577, PubMed:7859916). Plays an important role in maintaining glucocorticoids balance during preimplantation and protects the fetus from excessive maternal corticosterone exposure (By similarity). Catalyzes the oxidation of 11beta-hydroxytestosterone (11beta,17beta-dihydroxyandrost-4-ene-3-one) to 11-ketotestosterone (17beta-hydroxyandrost-4-ene-3,11-dione), a major bioactive androgen (PubMed:22796344, PubMed:27927697). Catalyzes the conversion of 11beta-hydroxyandrostenedione (11beta-hydroxyandrost-4-ene-3,17-dione) to 11-ketoandrostenedione (androst-4-ene-3,11,17-trione), which can be further metabolized to 11-ketotestosterone (PubMed:23685396, PubMed:27927697). Converts 7-beta-25-dihydroxycholesterol to 7-oxo-25-hydroxycholesterol in vitro (PubMed:30902677). 7-beta-25-dihydroxycholesterol (not 7-oxo-25-hydroxycholesterol) acts as a ligand for the G protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (PubMed:30902677). May protect ovulating oocytes and fertilizing spermatozoa from the adverse effects of cortisol (By similarity). Catalyzes the conversion of 7-beta-hydroxycholesterol into 7-ketocholesterol (7-oxocholesterol), a precursor of 7-keto,27-hydroxycholesterol, which activates smoothened (SMO) and the smoothened signaling pathway (By similarity)
Protein Sequence
10
MERWPWPSGG
20
AWLLVAARAL
30
LQLLRSDLRL
40
GRPLLAALAL
50
LAALDWLCQR
60
LLPPPAALAV
70
LAAAGWIALS
80
RLARPQRLPV
90
ATRAVLITGC
100
DSGFGKETAK
110
KLDSMGFTVL
120
ATVLELNSPG
130
AIELRTCCSP
140
RLRLLQMDLT
150
KPGDISRVLE
160
FTKAHTTSTG
170
LWGLVNNAGH
180
NEVVADAELS
190
PVATFRSCME
200
VNFFGALELT
210
KGLLPLLRSS
220
RGRIVTVGSP
230
AGDMPYPCLG
240
AYGTSKAAVA
250
LLMDTFSCEL
260
LPWGVKVSII
270
QPGCFKTESV
280
RNVGQWEKRK
290
QLLLANLPQE
300
LLQAYGKDYI
310
EHLHGQFLHS
320
LRLAMSDLTP
330
VVDAITDALL
340
AARPRRRYYP
350
GQGLGLMYFI
360
HYYLPEGLRR
370
RFLQAFFISH
380
CLPRALQPGQ
390
PGTTPPQDAA
400
QDPNLSPGPS
PAVAR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Molecular Function |
GO:0070523 |
11-beta-hydroxysteroid dehydrogenase (NAD+) activity |
| Molecular Function |
GO:0051287 |
NAD binding |
| Molecular Function |
GO:0005496 |
steroid binding |
| Biological Process |
GO:0034650 |
cortisol metabolic process |
| Biological Process |
GO:0007565 |
female pregnancy |
| Biological Process |
GO:0008211 |
glucocorticoid metabolic process |
| Biological Process |
GO:0002017 |
regulation of blood volume by renal aldosterone |
| Biological Process |
GO:0032094 |
response to food |
| Biological Process |
GO:0051384 |
response to glucocorticoid |
| Biological Process |
GO:0001666 |
response to hypoxia |
| Biological Process |
GO:0032868 |
response to insulin |
| Biological Process |
GO:0009410 |
response to xenobiotic stimulus |
Reference
PMID: N/A