Search Results

Overview

Uniprot IDP80404
Protein Name4-aminobutyrate aminotransferase, mitochondrial
Gene NameABAT
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
231 CLATTHSKAIHKIDI
252 IAPFPRLKYPLEEFV
260 YPLEEFVKENQQEEA
285 VKYRKKKKTVAGIIV
318 KLRDIARKHGCAFLV
358 DVMTFSKKMMTGGFF
367 MTGGFFHKEEFRPNA
400 AEVINIIKREDLLNN
413 NNAAHAGKALLTGLL
452 PDDSIRNKLILIARN
460 LILIARNKGVVLGGC
47 DYDGPLMKTEVPGPR
470 VLGGCGDKSIRFRPT

Function

Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively (PubMed:10407778, PubMed:15528998). Can also convert delta-aminovalerate and beta-alanine (By similarity)

Protein Sequence

10 MASMLLAQRL 20 ACSFQHSYRL 30 LVPGSRHISQ 40 AAAKVDVEFD 50 YDGPLMKTEV 60 PGPRSQELMK 70 QLNIIQNAEA 80 VHFFCNYEES 90 RGNYLVDVDG 100 NRMLDLYSQI 110 SSVPIGYSHP 120 ALLKLIQQPQ 130 NASMFVNRPA 140 LGILPPENFV 150 EKLRQSLLSV 160 APKGMSQLIT 170 MACGSCSNEN 180 ALKTIFMWYR 190 SKERGQRGFS 200 QEELETCMIN 210 QAPGCPDYSI 220 LSFMGAFHGR 230 TMGCLATTHS 240 KAIHKIDIPS 250 FDWPIAPFPR 260 LKYPLEEFVK 270 ENQQEEARCL 280 EEVEDLIVKY 290 RKKKKTVAGI 300 IVEPIQSEGG 310 DNHASDDFFR 320 KLRDIARKHG 330 CAFLVDEVQT 340 GGGCTGKFWA 350 HEHWGLDDPA 360 DVMTFSKKMM 370 TGGFFHKEEF 380 RPNAPYRIFN 390 TWLGDPSKNL 400 LLAEVINIIK 410 REDLLNNAAH 420 AGKALLTGLL 430 DLQARYPQFI 440 SRVRGRGTFC 450 SFDTPDDSIR 460 NKLILIARNK 470 GVVLGGCGDK 480 SIRFRPTLVF 490 RDHHAHLFLN 500 IFSDILADFK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0032144 4-aminobutyrate transaminase complex
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0047298 (S)-3-amino-2-methylpropionate transaminase activity
Molecular Function GO:0034386 4-aminobutyrate:2-oxoglutarate transaminase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0051536 iron-sulfur cluster binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0030170 pyridoxal phosphate binding
Molecular Function GO:0032145 succinate-semialdehyde dehydrogenase binding
Biological Process GO:0021549 cerebellum development
Biological Process GO:0007620 copulation
Biological Process GO:0035640 exploration behavior
Biological Process GO:0009449 gamma-aminobutyric acid biosynthetic process
Biological Process GO:0009450 gamma-aminobutyric acid catabolic process
Biological Process GO:0009448 gamma-aminobutyric acid metabolic process
Biological Process GO:0007626 locomotory behavior
Biological Process GO:0045776 negative regulation of blood pressure
Biological Process GO:0033602 negative regulation of dopamine secretion
Biological Process GO:0014053 negative regulation of gamma-aminobutyric acid secretion
Biological Process GO:0050877 nervous system process
Biological Process GO:1904450 positive regulation of aspartate secretion
Biological Process GO:0045964 positive regulation of dopamine metabolic process
Biological Process GO:0031652 positive regulation of heat generation
Biological Process GO:0097151 positive regulation of inhibitory postsynaptic potential
Biological Process GO:0032024 positive regulation of insulin secretion
Biological Process GO:1902722 positive regulation of prolactin secretion
Biological Process GO:0070474 positive regulation of uterine smooth muscle contraction
Biological Process GO:0042220 response to cocaine
Biological Process GO:0045471 response to ethanol
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0010039 response to iron ion
Biological Process GO:0035094 response to nicotine
Biological Process GO:0009410 response to xenobiotic stimulus

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.