Overview
| Uniprot ID | P80511 |
|---|
| Protein Name | Protein S100-A12 |
|---|
| Gene Name | S100A12 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 22 |
FHQYSVRKGHFDTLS |
| 30 |
GHFDTLSKGELKQLL |
Function
S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its pro-inflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of pro-inflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus
Protein Sequence
10
MTKLEEHLEG
20
IVNIFHQYSV
30
RKGHFDTLSK
40
GELKQLLTKE
50
LANTIKNIKD
60
KAVIDEIFQG
70
LDANQDEQVD
80
FQEFISLVAI
90
ALKAAHYHTH
KE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005856 |
cytoskeleton |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0034774 |
secretory granule lumen |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Molecular Function |
GO:0048306 |
calcium-dependent protein binding |
| Molecular Function |
GO:0005507 |
copper ion binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0050786 |
RAGE receptor binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0061844 |
antimicrobial humoral immune response mediated by antimicrobial peptide |
| Biological Process |
GO:0042742 |
defense response to bacterium |
| Biological Process |
GO:0050832 |
defense response to fungus |
| Biological Process |
GO:0043542 |
endothelial cell migration |
| Biological Process |
GO:0006954 |
inflammatory response |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0031640 |
killing of cells of another organism |
| Biological Process |
GO:0045576 |
mast cell activation |
| Biological Process |
GO:0002548 |
monocyte chemotaxis |
| Biological Process |
GO:0030593 |
neutrophil chemotaxis |
| Biological Process |
GO:0043123 |
positive regulation of canonical NF-kappaB signal transduction |
| Biological Process |
GO:0050729 |
positive regulation of inflammatory response |
| Biological Process |
GO:0043406 |
positive regulation of MAP kinase activity |
| Biological Process |
GO:0006805 |
xenobiotic metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.