Search Results
Overview
| Uniprot ID | P80895 |
|---|---|
| Protein Name | Protein-L-isoaspartate(D-aspartate) O-methyltransferase |
| Gene Name | PCMT1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 4 | ****MAWKSGGASHS |
Function
Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins (By similarity). Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity)
Protein Sequence
10
MAWKSGGASH
20
SELIHNLRKN
30
GIIKTDKVFE
40
VMLATDRSHY
50
AKCNPYMDSP
60
QSIGFQATIS
70
APHMHAYALE
80
LLFDQLHEGA
90
KALDVGSGSG
100
ILTACFARMV
110
GPSGKVIGID
120
HIKELVDDSI
130
NNVRKDDPML
140
LSSGRVQLVV
150
GDGRMGYAEE
160
APYDAIHVGA
170
AAPVVPQALI
180
DQLKPGGRLI
190
LPVGPAGGNQ
200
MLEQYDKLQD
210
GSVKMKPLMG
220
VIYVPLTDKE
KQWSRWK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity |
| Biological Process | GO:0006479 | protein methylation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.