Search Results
Overview
| Uniprot ID | P81155 |
|---|---|
| Protein Name | Non-selective voltage-gated ion channel VDAC2 |
| Gene Name | Vdac2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 121 | TFSPNTGKKSGKIKS |
| 32 | AARDIFNKGFGFGLV |
| 73 | VSGTLETKYKWCEYG |
| 75 | GTLETKYKWCEYGLT |
Function
Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (By similarity). The channel adopts an open conformation at zero mV and a closed conformation at both positive and negative potentials (By similarity). There are two populations of channels; the main that functions in a lower open-state conductance with lower ion selectivity, that switch, in a voltage-dependent manner, from the open to a low-conducting 'closed' state and the other that has a normal ion selectivity in the typical high conductance, 'open' state (By similarity). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (By similarity). Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (By similarity). Associates with the translocase of the outer mitochondrial membrane (TOM) complex and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001669 | acrosomal vesicle |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0042645 | mitochondrial nucleoid |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0046930 | pore complex |
| Cellular Component | GO:0097225 | sperm midpiece |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0097001 | ceramide binding |
| Molecular Function | GO:0015485 | cholesterol binding |
| Molecular Function | GO:0008142 | oxysterol binding |
| Molecular Function | GO:0031210 | phosphatidylcholine binding |
| Molecular Function | GO:0017128 | phospholipid scramblase activity |
| Molecular Function | GO:0015288 | porin activity |
| Molecular Function | GO:0008308 | voltage-gated monoatomic anion channel activity |
| Molecular Function | GO:0005244 | voltage-gated monoatomic ion channel activity |
| Biological Process | GO:0007339 | binding of sperm to zona pellucida |
| Biological Process | GO:0097345 | mitochondrial outer membrane permeabilization |
| Biological Process | GO:1990542 | mitochondrial transmembrane transport |
| Biological Process | GO:0006820 | monoatomic anion transport |
| Biological Process | GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway |
| Biological Process | GO:0032272 | negative regulation of protein polymerization |
| Biological Process | GO:0045332 | phospholipid translocation |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.