Overview
| Uniprot ID | P81605 |
|---|
| Protein Name | Dermcidin |
|---|
| Gene Name | DCD |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 82 |
KAVGGLGKLGKDAVE |
| 85 |
GGLGKLGKDAVEDLE |
| 96 |
EDLESVGKGAVHDVK |
Function
Found in sweat, has an antimicrobial activity during early bacterial colonization (PubMed:11694882, PubMed:23426625). The secreted peptide assembles into homohexameric complexes that can associate with and also insert into pathogen membranes (PubMed:23426625). Once inserted in bacteria membranes forms anion channels probably altering the transmembrane potential essential for bacterial survival (PubMed:23426625). Highly effective against E.coli, E.faecalis, S.aureus and C.albicans (PubMed:11694882). Optimal pH and salt concentration resemble the conditions in sweat (PubMed:11694882). Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues (PubMed:17448443)
Protein Sequence
10
MRFMTLLFLT
20
ALAGALVCAY
30
DPEAASAPGS
40
GNPCHEASAA
50
QKENAGEDPG
60
LARQAPKPRK
70
QRSSLLEKGL
80
DGAKKAVGGL
90
GKLGKDAVED
100
LESVGKGAVH
110
DVKDVLDSVL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0016020 |
membrane |
| Molecular Function |
GO:0008289 |
lipid binding |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0005216 |
monoatomic ion channel activity |
| Molecular Function |
GO:0008233 |
peptidase activity |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0061844 |
antimicrobial humoral immune response mediated by antimicrobial peptide |
| Biological Process |
GO:0042742 |
defense response to bacterium |
| Biological Process |
GO:0050832 |
defense response to fungus |
| Biological Process |
GO:0051873 |
killing by host of symbiont cells |
| Biological Process |
GO:0006508 |
proteolysis |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.