Overview
| Uniprot ID | P82460 |
|---|
| Protein Name | Thioredoxin |
|---|
| Gene Name | TXN |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 3 |
*****MVKQIESKYA |
| 39 |
CGPCKMIKPFFHSLS |
| 8 |
MVKQIESKYAFQEAL |
| 85 |
QFFKKGQKVGEFSGA |
| 94 |
GEFSGANKEKLEATI |
Function
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity)
Protein Sequence
10
MVKQIESKYA
20
FQEALNSAGE
30
KLVVVDFSAT
40
WCGPCKMIKP
50
FFHSLSEKYS
60
NVVFLEVDVD
70
DCQDVASECE
80
VKCMPTFQFF
90
KKGQKVGEFS
100
GANKEKLEAT
INELI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0015035 |
protein-disulfide reductase activity |
| Biological Process |
GO:0019725 |
cellular homeostasis |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0043388 |
positive regulation of DNA binding |
| Biological Process |
GO:0009314 |
response to radiation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.