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Overview

Uniprot IDP82970
Protein NameHigh mobility group nucleosome-binding domain-containing protein 5
Gene NameHMGN5
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
17 GDMRQEPKRRSARLS
37 VTPEVKPKRTSSSRK
48 SSRKMKTKSDMMEEN
5 ***MPKRKAAGQGDM

Function

Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction

Protein Sequence

10 MPKRKAAGQG 20 DMRQEPKRRS 30 ARLSAMLVPV 40 TPEVKPKRTS 50 SSRKMKTKSD 60 MMEENIDTSA 70 QAVAETKQEA 80 VVEEDYNENA 90 KNGEAKITEA 100 PASEKEIVEV 110 KEENIEDATE 120 KGGEKKEAVA 130 AEVKNEEEDQ 140 KEDEEDQNEE 150 KGEAGKEDKD 160 EKGEEDGKED 170 KNGNEKGEDA 180 KEKEDGKKGE 190 DGKGNGEDGK 200 EKGEDEKEEE 210 DRKETGDGKE 220 NEDGKEKGDK 230 KEGKDVKVKE 240 DEKEREDGKE 250 DEGGNEEEAG 260 KEKEDLKEEE 270 EGKEEDEIKE 280 DDGKKEEPQS IV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0031492 nucleosomal DNA binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006325 chromatin organization
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0006355 regulation of DNA-templated transcription

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[2] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.