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Overview

Uniprot IDP83686
Protein NameNADH-cytochrome b5 reductase 3
Gene NameCYB5R3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
127 LVYQGKGKFAIRPDK
21 YPLRLIDKEVVNHDT
266 LERVGHPKERCFAF*
86 LVIKVYFKDTHPKFP
91 YFKDTHPKFPAGGKM

Function

Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor

Protein Sequence

10 STPAITLENP 20 DIKYPLRLID 30 KEVVNHDTRR 40 FRFALPSPEH 50 ILGLPVGQHI 60 YLSARIDGNL 70 VIRPYTPVSS 80 DDDKGFVDLV 90 IKVYFKDTHP 100 KFPAGGKMSQ 110 YLESMKIGDT 120 IEFRGPNGLL 130 VYQGKGKFAI 140 RPDKKSSPVI 150 KTVKSVGMIA 160 GGTGITPMLQ 170 VIRAIMKDPD 180 DHTVCHLLFA 190 NQTEKDILLR 200 PELEELRNEH 210 SARFKLWYTV 220 DRAPEAWDYS 230 QGFVNEEMIR 240 DHLPPPEEEP 250 LVLMCGPPPM 260 IQYACLPNLE 270 RVGHPKERCF AF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H
Molecular Function GO:0090524 cytochrome-b5 reductase activity, acting on NADH
Molecular Function GO:0071949 FAD binding
Molecular Function GO:0050660 flavin adenine dinucleotide binding
Biological Process GO:0006695 cholesterol biosynthetic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.