Search Results
Overview
| Uniprot ID | P83868 |
|---|---|
| Protein Name | Prostaglandin E synthase 3 |
| Gene Name | Ptges3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 33 | DVNVNFEKSKLTFSC |
Function
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0101031 | protein folding chaperone complex |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0005697 | telomerase holoenzyme complex |
| Molecular Function | GO:0070182 | DNA polymerase binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0051879 | Hsp90 protein binding |
| Molecular Function | GO:0002039 | p53 binding |
| Molecular Function | GO:0050220 | prostaglandin-E synthase activity |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Molecular Function | GO:0003720 | telomerase activity |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0008283 | cell population proliferation |
| Biological Process | GO:0051131 | chaperone-mediated protein complex assembly |
| Biological Process | GO:0019371 | cyclooxygenase pathway |
| Biological Process | GO:0005978 | glycogen biosynthetic process |
| Biological Process | GO:0060430 | lung saccule development |
| Biological Process | GO:0051402 | neuron apoptotic process |
| Biological Process | GO:0042921 | nuclear receptor-mediated glucocorticoid signaling pathway |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0032212 | positive regulation of telomere maintenance via telomerase |
| Biological Process | GO:0001516 | prostaglandin biosynthetic process |
| Biological Process | GO:0006693 | prostaglandin metabolic process |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0043588 | skin development |
| Biological Process | GO:1905323 | telomerase holoenzyme complex assembly |
| Biological Process | GO:0007004 | telomere maintenance via telomerase |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.