Search Results
Overview
| Uniprot ID | P83916 |
|---|---|
| Protein Name | Chromobox protein homolog 1 |
| Gene Name | CBX1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | EESKPKKKKEESEKP |
| 104 | ESKPKKKKEESEKPR |
| 35 | DRRVVKGKVEYLLKW |
| 8 | MGKKQNKKKVEEVLE |
| 9 | GKKQNKKKVEEVLEE |
Function
Component of heterochromatin, which recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression (PubMed:41094145). Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me) (PubMed:16127177). Excluded from chromatin when histone H1.4 is Simultaneously methylated at Lys-26 (H1.4K26me) and phosphorylated at Ser-27 (H1.4S27Ph) (PubMed:16127177). Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0010369 | chromocenter |
| Cellular Component | GO:0000775 | chromosome, centromeric region |
| Cellular Component | GO:0000781 | chromosome, telomeric region |
| Cellular Component | GO:0001939 | female pronucleus |
| Cellular Component | GO:0000792 | heterochromatin |
| Cellular Component | GO:0001940 | male pronucleus |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005721 | pericentric heterochromatin |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Cellular Component | GO:0090734 | site of DNA damage |
| Cellular Component | GO:0005819 | spindle |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0160267 | histone H1K26me1 reader activity |
| Molecular Function | GO:0160268 | histone H1K26me2 reader activity |
| Molecular Function | GO:0062072 | histone H3K9me2/3 reader activity |
| Molecular Function | GO:1990226 | histone methyltransferase binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0031507 | heterochromatin formation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.
[4] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.
[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.
[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.