Search Results
Overview
| Uniprot ID | P84076 |
|---|---|
| Protein Name | Neuron-specific calcium-binding protein hippocalcin |
| Gene Name | Hpca |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 137 | KMVSSVMKMPEDEST |
| 174 | EEFIRGAKSDPSIVR |
Function
Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels (By similarity). May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases (PubMed:15336960)
Protein Sequence
10
MGKQNSKLRP
20
EMLQDLRENT
30
EFSELELQEW
40
YKGFLKDCPT
50
GILNVDEFKK
60
IYANFFPYGD
70
ASKFAEHVFR
80
TFDTNSDGTI
90
DFREFIIALS
100
VTSRGRLEQK
110
LMWAFSMYDL
120
DGNGYISREE
130
MLEIVQAIYK
140
MVSSVMKMPE
150
DESTPEKRTE
160
KIFRQMDTNN
170
DGKLSLEEFI
180
RGAKSDPSIV
190
RLLQCDPSSA
SQF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0032839 | dendrite cytoplasm |
| Cellular Component | GO:0032590 | dendrite membrane |
| Cellular Component | GO:0044327 | dendritic spine head |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0032809 | neuronal cell body membrane |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0098794 | postsynapse |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019900 | kinase binding |
| Biological Process | GO:0019722 | calcium-mediated signaling |
| Biological Process | GO:0071277 | cellular response to calcium ion |
| Biological Process | GO:0071257 | cellular response to electrical stimulus |
| Biological Process | GO:1905232 | cellular response to L-glutamate |
| Biological Process | GO:0048839 | inner ear development |
| Biological Process | GO:0031283 | negative regulation of guanylate cyclase activity |
| Biological Process | GO:0045762 | positive regulation of adenylate cyclase activity |
| Biological Process | GO:0010518 | positive regulation of phospholipase activity |
| Biological Process | GO:0090314 | positive regulation of protein targeting to membrane |
| Biological Process | GO:0099149 | regulation of postsynaptic neurotransmitter receptor internalization |
| Biological Process | GO:0009966 | regulation of signal transduction |
| Biological Process | GO:1901385 | regulation of voltage-gated calcium channel activity |
| Biological Process | GO:1904010 | response to Aroclor 1254 |
| Biological Process | GO:1901986 | response to ketamine |
| Biological Process | GO:1902065 | response to L-glutamate |
| Biological Process | GO:0060041 | retina development in camera-type eye |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.