Search Results
Overview
| Uniprot ID | P84077 |
|---|---|
| Protein Name | ADP-ribosylation factor 1 |
| Gene Name | ARF1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 73 | WDVGGQDKIRPLWRH |
Function
Small GTPase involved in protein trafficking between different compartments (PubMed:8253837). Modulates vesicle budding and uncoating within the Golgi complex (PubMed:8253837). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (PubMed:8253837). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (PubMed:8253837). The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD) (By similarity). Plays a key role in the regulation of intestinal stem cells and gut microbiota, and is essential for maintaining intestinal homeostasis (By similarity). Also plays a critical role in mast cell expansion but not in mast cell maturation by facilitating optimal mTORC1 activation (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031252 | cell leading edge |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0030017 | sarcomere |
| Molecular Function | GO:0003925 | G protein activity |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0098586 | cellular response to virus |
| Biological Process | GO:0097061 | dendritic spine organization |
| Biological Process | GO:0006878 | intracellular copper ion homeostasis |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0060292 | long-term synaptic depression |
| Biological Process | GO:1990386 | mitotic cleavage furrow ingression |
| Biological Process | GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation |
| Biological Process | GO:0002090 | regulation of receptor internalization |
| Biological Process | GO:0016192 | vesicle-mediated transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.